Domestic Cases of Hemorrhagic Fever with Renal Syndrome in the United StatesGlass G.E. · Watson A.J. · LeDuc J.W. · Childs J.E.
aDepartment of Immunology and Infectious Diseases, Johns Hopkins School of Hygiene and Public Health, Johns Hopkins University, and bDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Md., cDepartment of Epidemiology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Md., USA
Although serologic studies have identified hantaviral infection in the United States, acute disease has not been recognized. This study describes 3 cases of domestically acquired hemorrhagic fever with renal syndrome (HFRS) in the United States. Infection was due to a local strain of Seoul virus (Baltimore rat virus). A review of the clinical features indicated a mild illness characterized by nausea, vomiting, renal and liver failure similar to HFRS described elsewhere for rat-borne viruses. Follow-up of 2 patients identified persitent hypertension and renal disease providing further evidence of an association between past hantaviral infection and hypertensive renal disease.
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