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Vol. 149, No. 2, 2009
Issue release date: May 2009
Int Arch Allergy Immunol 2009;149:133–140
(DOI:10.1159/000189196)

Association between Obesity and Atopy in Chinese Schoolchildren

Leung T.F. · Kong A.P.S. · Chan I.H.S. · Choi K.C. · Ho C.S. · Chan M.H.M. · So W.Y. · Lam C.W.K. · Wong G.W.K. · Chan J.C.N.
Departments of aPaediatrics, bMedicine and Therapeutics and cChemical Pathology, dCenter for Epidemiology and Biostatistics, eLi Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China

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Abstract

Background: Despite parallel increases in asthma and obesity prevalence, there is little data on obesity as a risk factor for atopy. The latter is an important phenotype in asthmatic patients. This study investigates the association between asthma traits, atopy and obesity-related markers in Chinese adolescents. Methods: 486 schoolchildren were recruited among participants of our population-based study on the epidemiology of obesity, and their allergy status was ascertained using a standardized questionnaire. Subjects’ anthropometry was recorded on-site, and fasting blood was collected for allergen-specific immunoglobulin E (IgE), lipids and systemic inflammatory biomarkers. Results: 98 (20.2%) subjects were classified as overweight or obese. Obesity status was not associated with asthma, allergic rhinitis or eczema (p > 0.25). Atopy was not associated with age-adjusted body mass index (BMI) or waist circumference. Atopy and presence of allergen-specific IgE did not differ between overweight or obese children and those with normal BMI (p > 0.25), although subgroup analysis suggested that cockroach sensitization was more common among males who were obese or overweight (p = 0.045). White cell count (WCC) was higher among atopic than nonatopic children (mean values 6.5 × 109/l vs. 6.2 × 109/l, p = 0.006). Logistic regression revealed WCC to be the only risk factor for atopy (OR 18.97, p = 0.004). Conclusions: Obesity is not associated with asthma or atopy in Chinese children. High WCC is an important risk factor for atopy in both males and females. Gender does not exert any consistent effect on the association between obesity and allergen sensitization in children.



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References

  1. Shaheen SO, Sterne JAC, Montgomery SM, Azima H: Birth weight, body mass index and asthma in young adults. Thorax 1999;54:396–402.
  2. Hancox RJ, Milne BJ, Poulton R, Taylor DR, Greene JM, McLachlan CR, Cowan JO, Flannery EM, Herbison GP, Sears MR: Sex differences in the relation between body mass index and asthma and atopy in a birth cohort. Am J Respir Crit Care Med 2005;171:440–445.
  3. Belamarich PF, Luder E, Kattan M, Mitchell H, Islam S, Lynn H, Crain EF: Do obese inner-city children with asthma have more symptoms than nonobese children with asthma? Pediatrics 2000;106:1436–1441.
  4. von Mutius E, Schwartz J, Neas LM, Dockery D, Weiss ST: Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax 2001;56:835–838.
  5. Chen Y, Rennie D, Cormier Y, Dosman J: Sex specificity of asthma associated with objectively measured body mass index and waist circumference: the Humboldt study. Chest 2005;128:3048–3054.
  6. Mannino DM, Mott J, Ferdinands JM, Camargo Jr CA, Friedman M, Greves HM, Redd SC: Boys with high body masses have an increased risk of developing asthma: findings from the National Longitudinal Survey of Youth (NLSY). Int J Obes 2006;30:6–13.
  7. Schachter LM, Peat JK, Salome CM: Asthma and atopy in overweight children. Thorax 2003;58:1031–1035.
  8. Beuther DA, Sutherland ER: Overweight, obesity and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 2007;175:661–666.
  9. Flaherman V, Rutherford GW: A meta-analysis of the effect of high weight on asthma. Arch Dis Child 2006;91:334–339.
  10. Weiss ST: Obesity: insights into the origins of asthma. Nat Immunol 2005;6:537–539.
  11. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB: Elevated C-reactive protein levels in overweight and obese adults. JAMA 1999;282:2131–2135.
  12. Leung TF, Li CY, Lam CW, Au CS, Yung E, Chan IH, Wong GW, Fok TF: The relation between obesity and asthmatic airway inflammation. Pediatr Allergy Immunol 2004;15:344–350.
  13. Santamaria F, Montella S, Stefano SD, Sperli F, Barbarano F, Valerio G: Relationship between exhaled nitric oxide and body mass index in children and adolescents. J Allergy Clin Immunol 2005;116:1163–1164.
  14. Platts-Mills TA, Rakes G, Heymann PW: The relevance of allergen exposure to the development of asthma in childhood. J Allergy Clin Immunol 2000;105:S503–S508.
  15. Oryszczyn M-P, Bouzigon E, Maccario J, Siroux V, Nadif R, Wright A, Kauffmann F: Interrelationships of quantitative asthma related phenotypes in the Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy. J Allergy Clin Immunol 2007;119:57–63.
  16. Leung TF, Lam CW, Chan IH, Li AM, Ha G, Tang NL, Fok TF: Inhalant allergens as risk factors for the development and severity of mild-to-moderate asthma in Hong Kong Chinese children. J Asthma 2002;39:323–330.
  17. Radon K, Schulze A: Adult obesity, farm childhood, and their effect on allergic sensitization. J Allergy Clin Immunol 2006;118:1279–1283.
  18. Vieira VJ, Ronan AM, Windt MR, Tagliaferro AR: Elevated atopy in healthy obese women. Am J Clin Nutr 2005;82:504–509.
  19. Jarvis D, Chinn S, Potts J, Burney P, the European Community Respiratory Health Survey: Association of body mass index with respiratory symptoms and atopy: results from the European Community Respiratory Health Survey. Clin Exp Allergy 2002;32:831–837.
  20. Ozaki R, Qiao Q, Wong GW, Chan MH, So WY, Tong PC, Ho SC, Ko GT, Kong AP, Lam CW, Tuomilehto J, Chan JC: Overweight, family history of diabetes and attending schools of lower academic grading are independent predictors for metabolic syndrome in Hong Kong Chinese adolescents. Arch Dis Child 2007;92:224–228.
  21. Wong GW, Leung TF, Ko FW, Lee KK, Lam P, Hui DS, Fok TF, Lai CK: Declining asthma prevalence in Hong Kong Chinese schoolchildren. Clin Exp Allergy 2004;34:1550–1555.
  22. Leung SS, Cole TJ, Tse LY, Lau JT: Body mass index reference curves for Chinese children. Ann Hum Biol 1998;25:169–174.
  23. Ng VW, Kong AP, Choi KC, Ozaki R, Wong GW, So WY, Tong PC, Sung RY, Xu LY, Chan HM, Ho CS, Lam CW, Chan JC: Use of BMI and waist circumference to predict clustering of cardiovascular risk factors in Hong Kong Chinese adolescents. Obesity 2007;15:1–10.

    External Resources

  24. Leung TF, Tang NL, Li CY, Lam CW, Wong GW, Fok TF: Association between TARC C-431T and atopy and asthma in children. J Allergy Clin Immunol 2004;114:199–202.
  25. Appleton SL, Adams RJ, Wilson DH, Taylor AW, Ruffin RE, on behalf of the North West Adelaide Health Study Team: Central obesity is associated with nonatopic but not atopic asthma in a representative population sample. J Allergy Clin Immunol 2006;118:1284–1291.
  26. Chen Y, Dales R, Jiang Y: The association between obesity and asthma is stronger in nonallergic than allergic adults. Chest 2006;130:890–895.
  27. Jacobson JS, Mellins RB, Garfinkel R, Rundle AG, Perzanowski MS, Chew GL, Andrews HF, Goldstein IF: Asthma, body mass, gender, and Hispanic national origin among 517 preschool children in New York City. Allergy 2008;63:87–94.
  28. Huang SL, Shiao GM, Chou P: Association between body mass index and allergy in teenage girls in Taiwan. Clin Exp Allergy 1999;29:323–329.
  29. Braun-Fahrländer C, Riedler J, Herz U, Eder W, Waser M, Grize L, Maisch S, Carr D, Gerlach F, Bufe A, Lauener RP, Schierl R, Renz H, Nowak D, von Mutius E, for the Allergy and Endotoxin Study Team: Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002;347:869–877.
  30. Borish L, Chipps B, Deniz Y, Gujrathi S, Zheng B, Dolan CM, and TENOR Study Group: Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol 2005;95:247–253.
  31. Celedón JC, Litonjua AA, Ryan L, Weiss ST, Gold DR: Day care attendance, respiratory tract illnesses, wheezing, asthma, and total serum IgE level in early childhood. Arch Pediatr Adolesc Med 2002;156:241–245.
  32. McKune AJ, Smith LL, Semple SJ, Mokethwa B, Wadee AA: Immunoglobulin responses to a repeated bout of downhill running. Br J Sports Med 2006;40:844–849.
  33. Brooker S, Clements AC, Bundy DA: Global epidemiology, ecology and control of soil-transmitted helminth infections. Adv Parasitol 2006;62:221–261.
  34. Leung TF, Wong GW, Ko FW, Lam CW, Fok TF: Clinical and atopic parameters and airway inflammatory markers in childhood asthma: a factor analysis. Thorax 2005;60:822–826.


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