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Vol. 71, No. 2, 2009
Issue release date: April 2009
ORL 2009;71:78–86

Ménière’s Disease Is a Viral Neuropathy

Gacek R.R.
Department of Otolaryngology – Head and Neck Surgery, University of Massachusetts Medical School, Worcester, Mass., USA

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Morphological and clinical evidence supports a viral neuropathy in Ménière’s disease (MD). Quantitative examination of 11 sectioned temporal bones (TBs) from 8 patients with a history of MD revealed a significant loss of vestibular ganglion cells in both the endolymph hydropic (EH) and non-EH ears. Transmission electron microscopy of vestibular ganglion cells excised from a patient with MD revealed viral particles enclosed in transport vesicles. Antiviral treatment controlled vertigo in 73 of 86 patients with vestibular neuronitis (85%) and 32 of 35 patients with MD (91%).

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