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Kidney Blood Press Res 2008;31:421–432

A Mutation in the Mouse Chd2 Chromatin Remodeling Enzyme Results in a Complex Renal Phenotype

Marfella C.G.A.a · Henninger N.b · LeBlanc S.E.a · Krishnan N.c · Garlick D.S.d · Holzman L.B.e · Imbalzano A.N.a
Departments of aCell Biology and bNeurology, cRenal Division, Department of Internal Medicine, and dDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, Mass., and eDivision of Nephrology, University of Michigan Medical School, Ann Arbor, Mich., USA
email Corresponding Author

 goto top of outline Key Words

  • Chd2
  • Chromatin remodeling enzyme
  • Glomerular disease
  • Proteinuria
  • Anemia

 goto top of outline Abstract

Background and Aims: Glomerular diseases are the third leading cause of kidney failure worldwide, behind only diabetes and hypertension. The molecular mechanisms underlying the cause of glomerular diseases are still largely unknown. The identification and characterization of new molecules associated with glomerular function should provide new insights into understanding the diverse group of glomerular diseases. The Chd2 protein belongs to a family of enzymes involved in ATP-dependent chromatin remodeling, suggesting that it likely functions as an epigenetic regulator of gene expression via the modification of chromatin structure. Methods: In this study, we present a detailed histomorphologic characterization of mice containing a mutation in the chromodomain helicase DNA-binding protein 2 (Chd2). Results: We show that Chd2-mutant mice present with glomerulopathy, proteinuria, and significantly impaired kidney function. Additionally, serum analysis revealed decreased hemoglobin and hematocrit levels in Chd2-mutant mice, suggesting that the glomerulopathy observed in these mice is associated with anemia. Conclusion: Collectively, the data suggest a role for the Chd2 protein in the maintenance of kidney function.

Copyright © 2009 S. Karger AG, Basel

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 goto top of outline Author Contacts

Anthony N. Imbalzano
Department of Cell Biology, University of Massachusetts Medical School
55 Lake Avenue North, Worcester, MA 01655 (USA)
Tel. +1 508 856 1029, Fax +1 508 856 5612

 goto top of outline Article Information

Received: September 30, 2008
Accepted: November 17, 2008
Published online: January 14, 2009
Number of Print Pages : 12
Number of Figures : 5, Number of Tables : 2, Number of References : 42

 goto top of outline Publication Details

Kidney and Blood Pressure Research

Vol. 31, No. 6, Year 2008 (Cover Date: February 2009)

Journal Editor: Wanner C. (Würzburg)
ISSN: 1420-4096 (Print), eISSN: 1423-0143 (Online)

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