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Table of Contents
Vol. 55, No. 1, 1994
Issue release date: 1994
Section title: Original Paper
Digestion 1994;55:40–43
(DOI:10.1159/000201121)

Lymphocyte Proliferation Response to Baker’s Yeast in Crohn’s Disease

Young C.A. · Sonnenberg A. · Burns E.A.
Division of Gastroenterology, VA Medical Center, and Medical College of Wisconsin, Milwaukee, Wisc, USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/30/1993
Published online: 2/5/2009

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

The etiology of Crohn’s disease is still unknown. The present study served to test the hypothesis that baker’s yeast (Saccharomyces cerevisiae) plays a role in Crohn’s disease. Blood samples were obtained from 12 patients and 15 healthy controls. Peripheral blood leukocytes were isolated and incubated alone or with different concentrations of baker’s yeast. After 3 days, the cultures were pulsed with tritiated thymidine. None of the lymphocyte cultures from healthy controls, including 3 bakers, proliferated in response to yeast. In striking contrast, all 9 patients with Crohn’s disease in remission, on no medication, showed a threefold increase in their lymphocyte proliferation rate. Lymphocytes from 3 patients on 1.5 g of olsalazine maintenance therapy failed to respond. These results are consistent with previous findings that showed increased titers of IgG and IgA antibodies to baker’s yeast in patients with Crohn’s disease as compared to healthy controls. They confirm the suspicion that baker’s yeast itself or a related antigen play a role in Crohn’s disease and suggest that anti-inflammatory agents may act, in part, by inhibiting lymphocyte proliferation.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/30/1993
Published online: 2/5/2009

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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