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Table of Contents
Vol. 85, No. 2, 1991
Issue release date: 1991
Section title: Original Paper
Acta Haematol 1991;85:93–99
(DOI:10.1159/000204864)

Prognosis of Children with Virus-Associated Hemophagocytic Syndrome and Malignant Histiocytosis: Correlation with Levels of Serum Interleukin-1 and Tumor Necrosis Factor

Ishii E. · Ohga S. · Aoki T. · Yamada S. · Sako M. · Tasaka H. · Kuwano A. · Sasaki M. · Tsunematsu Y.T. · Ueda K.
aDepartment of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka; bInfectious Diseases Division, Fukuoka Municipal Children’s ospital Medical Center, Fukuoka; cDivision of Pediatrics, Osaka Children’s Health Center, Osaka; dSection of Pediatrics, National Kyushu Cancer Center, Fukuoka; eDepartment of ediatrics, Faculty of Medicine, Yamaguchi University, Yamaguchi; fDivision of Pediatrics, Urawa City Hospital, Chiba; gDivision of Hematology, National Children’s Hospital, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/31/1990
Accepted: 11/5/1990
Published online: 2/20/2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

To clarify the correlation of cytokine level with the severity and prognosis of children with the hemophagocytic syndrome, we analyzed serum interleukin-1 (IL-1) and tumor necrosis factor (TNF) levels in 26 children with either the virus-associated hemophagocytic syndrome (VAHS, n = 12) or malignant histiocytosis (MH, n = 14). When compared to healthy controls, 13 children had an elevated IL-1 ( ≥ 20 pg/ml) and 21 children had an elevated TNF ( ≥10 pg/ml) level at diagnosis. There was, however, no significant difference in the frequency of these high levels between the patients with VAHS and MH. Neither IL-1 nor TNF levels correlated with other clinical or laboratory findings in either VAHS or MH. Two of the 12 patients with VAHS died of an intracranial hemorrhage and 7 of the 14 patients with MH died despite chemotherapy. The MH patients who had a high TNF level (≥50 pg/ml) had a poorer prognosis than those with a low TNF level ( < 50 pg/ml; p < 0.01). In MH patients, other parameters, such as coagulopathy and lactic dehydrogenase, ferritin and IL-1 levels, did not correlate with prognosis. In 3 patients (2 with VAHS and 1 with MH) analyzed periodically, the change in TNF level was closely associated with the clinical progression or regression of the diseases. Serum cytokine levels may thus be monitored not only for predicting the severity and prognosis of VAHS or MH but also for determining the indications for or timing of chemotherapy. Moreover, TNF may play an important role in the progression of VAHS and MH.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/31/1990
Accepted: 11/5/1990
Published online: 2/20/2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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