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Vol. 27, No. 4, 2009
Issue release date: April 2009
Section title: Original Paper
Cerebrovasc Dis 2009;27:375–383
(DOI:10.1159/000207441)

Is Antioxidant and n–3 Supplementation Able to Improve Functional Status in Poststroke Patients? Results from the Nutristroke Trial

Garbagnati F. · Cairella G. · De Martino A. · Multari M. · Scognamiglio U. · Venturiero V. · Paolucci S.
aCentro Studi Alimentazione e Riabilitazione, IRCCS Fondazione S. Lucia, bDepartment of Biology, University of Rome Tor Vergata, and cIRCCS Fondazione S. Lucia, Rome, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/10/2008
Accepted: 11/25/2008
Published online: 3/10/2009

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 6

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: To test whether supplementary antioxidants and n–3 fatty acids, alone or in combination, could improve functional status in stroke survivors. Methods: We performed a randomized, double-blind, placebo-controlled clinical trial in 72 stroke patients (47 males; age 65.3 ± 12.9 years) admitted to a rehabilitation hospital for sequelae of first-ever ischemic stroke, and divided them into 4 subgroups. Group 1 patients received daily oral antioxidants, group 2 received n–3 polyunsaturated fatty acids, group 3 both supplements, and group 4 placebo, all for 12 months. No difference at baseline was observed among groups in neurological severity or in disability. All measures were repeated after 6 and 12 months of treatment. All major clinical events were recorded. Results: At baseline, 25% of the patients had a low plasma vitamin status, and 48.5% was at risk of undernutrition. At the 1-year follow-up, we observed a trend for lower mortality (p = 0.060) in subgroups treated with n–3 fatty acids, but without significant differences in rehabilitation result status among groups. Conclusions: Malnutrition is widely observed in patients admitted to a rehabilitative hospital for stroke rehabilitation, and dietary supplementation, even if not able to improve rehabilitation results, is likely to reduce mortality at the 1-year follow-up.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/10/2008
Accepted: 11/25/2008
Published online: 3/10/2009

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 6

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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