- Prenatal cocaine
- Cognitive development
This study investigated the potential long-term effects of cocaine exposure on brain functioning using fMRI in school-aged children. The sample included 12 children with prenatal cocaine exposure and 12 non-exposed children (8–9 years old). Groups did not differ on IQ, socioeconomic status, or perinatal risk factors. A response inhibition task was administered during an fMRI scan using a 1.5-T MRI system. Task performance did not differentiate groups, but groups were differentiated by patterns of task-related brain activity. Cocaine-exposed children showed greater activation in the right inferior frontal cortex and caudate during response inhibition, whereas non-exposed children showed greater activations in temporal and occipital regions. These preliminary findings suggest that prenatal cocaine may affect the development of brain systems involved in the regulation of attention and response inhibition.
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- Volpe JJ: Effect of cocaine use on the fetus. New Engl J Med 1992;327:399–407.
- Mayes LC: A behavioral teratogenic model of the impact of prenatal cocaine exposure on arousal regulatory systems. Neurotoxicol Teratol 2002;24:385–395.
- Glatt SJ, Bolaños CA, Trksak GH, Jackson D: Effects of prenatal cocaine exposure on dopamine system development: a meta-analysis. Neurotoxicol Teratol 2000;22:617–629.
- Lester BM, LaGasse LL, Seifer R: Prenatal cocaine exposure and child outcome: the meaning of subtle effects. Science 1998;282:633–634.
- Hurt H, Giannetta JM, Korczykowski M, Hoang A, Tang KZ, Betancourt L, Brodsky NL, Shera DM, Farah MJ, Detre JA: Functional magnetic resonance imaging and working memory in adolescents with gestational cocaine exposure. J Pediatr 2008;152:371–377.
- Smith LM, Chang L, Yonekura ML, Gilbride K, Kuo J, Poland RE, Walot I, Ernst T: Brain proton magnetic resonance spectroscopy and imaging in children exposed to cocaine in utero. Pediatrics 2001;107:227–231.
- Warner TD, Behnke M, Eyler FD, Padgett K, Leonard C, Hou W, Garvan CW, Schmalfuss IM, Blackband SJ: Diffusion tensor imaging of frontal white matter and executive functioning in cocaine-exposed children. Pediatrics 2006;118:2014–2024.
- Avants BB, Hurt H, Giannetta JM, Epstein CL, Shera DM, Rao H, Wang J, Gee JC: Effects of heavy in utero cocaine exposure on adolescent caudate morphology. Pediatr Neurol 2007;37:275–279.
- Rao H, Wang J, Giannetta J, Korczykowski M, Shera D, Avants BB, Gee J, Detre JA, Hurt H: Altered resting cerebral blood flow in adolescents with in utero cocaine exposure revealed by perfusion functional MRI. Pediatrics 2007;120:e1245–e1254.
- Scher MS, Richardson GA, Day NL: Effects of prenatal cocaine/crack and other drug exposure on electroencephalographic sleep studies at birth and one year. Pediatrics 2000;105:39–48.
- Lester BM, Lagasse L, Seifer R, Tronick EZ, Bauer CR, Shankaran S, Bada HS, Wright LL, Smeriglio VL, Liu J, Finnegan LP, Maza PL: The Maternal Lifestyle Study (MLS): effects of prenatal cocaine and/or opiate exposure on auditory brain response at one month. J Pediatr 2003;142:279–285.
- Bolla KI, Rothman R, Cadet JL: Dose-related neurobehavioral effects of chronic cocaine use. J Neuropsychiatry Clin Neurosci 1999;11:361–369.
- Fein G, Di Sclafani V, Meyerhoff DJ: Prefrontal cortical volume reduction associated with frontal cortex function deficit in 6-week abstinent crack-cocaine dependent men. Drug Alcohol Depend 2002;68:87–93.
- Levitt P: Prenatal effects of drugs of abuse on brain development. Drug Alcohol Depend 1998;51:109–125.
- Murphy EH, Fischer I, Friedman E, Grayson D, Jones L, Levitt P, O’Brien-Jenkins A, Wang HY, Wang XH: Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures. Exp Brain Res 1997;114:433–441.
- Bada HS, Das A, Bauer CR, Shankaran S, Lester B, LaGasse L, Hammond J, Wright LL, Higgins R: Impact of prenatal cocaine exposure on child behavior problems through school age. Pediatrics 2007;119:e348–e359.
- Casey BJ, Castellanos FX, Giedd JN, Marsh WL, Hamburger SD, Schubert AB, Vauss YC, Vaituzis AC, Dickstein DP, Sarfatti SE, Rapoport JL: Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 1997;36:374–383.
- Durston S, Tottenham NT, Thomas KM, Davidson MC, Eigsti IM, Yang Y, Ulug AM, Casey BJ: Differential patterns of striatal activation in young children with and without ADHD. Biol Psychiatry 2003;53:871–878.
- Bolla KI, Cadet JL, London ED: The neuropsychiatry of chronic cocaine abuse. J Neuropsychiatry Clin Neurosci 1998;10:280–289.
- Lester BM, Tronick EZ, LaGasse L, Seifer R, Bauer CR, Shankaran S, Bada HS, Wright LL, Smeriglio VL, Lu J, Finnegan LP, Maza PL: The maternal lifestyle study: effects of substance exposure during pregnancy on neurodevelopmental outcome in 1-month-old infants. Pediatrics 2002;110:1182–1192.
- Lester BM, ElSohly M, Wright LL, Smeriglio VL, Verter J, Bauer CR, Shankaran S, Bada HS, Walls HH, Huestis MA, Finnegan LP, Maza PL: The Maternal Lifestyle Study: drug use by meconium toxicology and maternal self-report. Pediatrics 2001;107:309–317.
- Durston S, Thomas KM, Yang Y, Uluğ AM, Zimmerman RD, Casey BJ: A neural basis for development of inhibitory control. Dev Sci 2002;5:F9–F16.
- Dale AM, Buckner RL: Selective averaging of rapidly presented individual trials using fMRI. Hum Brain Mapp 1997;5:329–340.
- Kwong KK, Belliveau JW, Chesler DA, et al: Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 1992;89:5675–5679.
- Cox RW: AFNI: software for the analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 1996;29:162–173.
- Talairach J, Tournoux P: Co-planar Stereotaxic Atlas of the Human Brain. New York, Thieme, 1988.
- Mazziotta JC, Toga AW, Evans A, Fox P, Lancaster J: A probabilistic atlas of the human brain: theory and rationale for its development. The International Consortium for Brain Mapping (ICBM). Neuroimage 1995;2:89–101.
- Rubia K, Smith AB, Taylor E, Brammer M: Linear age-correlated functional development of right inferior fronto-striato-cerebellar networks during response inhibition and anterior cingulate during error-related processes. Hum Brain Mapp 2007;28:1163–1177.
- Bunge SA, Dudukovic NM, Thomason ME, Vaidya CJ, Gabrieli JD: Immature frontal lobe contributions to cognitive control in children: evidence from fMRI. Neuron 2002;33:301–311.
- Tamm L, Menon V, Reiss AL: Maturation of brain function associated with response inhibition. J Am Acad Child Adolesc Psychiatry 2002;41:1231–1238.
- Di Sclafani V, Tolou-Shams M, Price LJ, Fein G: Neuropsychological performance of individuals dependent on crack-cocaine, or crack-cocaine and alcohol, at 6 weeks and 6 months of abstinence. Drug Alcohol Depend 2002;66:161–171.
- Bartzokis G, Beckson M, Lu PH, Edwards N, Bridge P, Mintz J: Brain maturation may be arrested in chronic cocaine addicts. Biol Psychiatry 2002;51:605–611.
- Lim KO, Choi SJ, Pomara N, Wolkin A, Rotrosen JP: Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study. Biol Psychiatry 2002;51:890–895.
- Franklin TR, Acton PD, Maldjian JA, Gray JD, Croft JR, Dackis CA, O’Brien CP, Childress AR: Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients. Biol Psychiatry 2002;51:134–142.
- Reader TA, Masse P, de Champlain J: The intracortical distribution of norepinephrine, dopamine and serotonin in the cerebral cortex of the cat. Brain Res 1979;177:499–513.
- Huang CC, Lin HJ, Hsu KS: Repeated cocaine administration promotes long-term potentiation induction in rat medial prefrontal cortex. Cereb Cortex 2007;17:1877–1888.
- Crandall JE, Hackett HE, Tobet SA, Kosofsky BE, Bhide PG: Cocaine exposure decreases GABA neuron migration from the ganglionic eminence to the cerebral cortex in mice. Cereb Cortex 2004;14:665–675.
- Jansma JM, Ramsey NF, Slagter HA, Kahn RS: Functional anatomical correlates of controlled and automatic processing. J Cogn Neurosci 2001;13:730–743.
- Garavan H, Kelley D, Rosen A, Rao SM, Stein EA: Practice-related functional activation changes in a working memory task. Microsc Res Tech 2000;51:54–63.
- Shaffer D, Schwab-Stone M, Fisher P, Cohen P, Piacentini J, Davies M, Conners CK, Regier D: The Diagnostic Interview Schedule for Children-Revised Version (DISC-R). I. Preparation, field testing, interrater reliability, and acceptability. J Am Acad Child Adoles Psychiatry 1993;32:643–650.
- Kesler SR, Vohr B, Schneider KC, Katz KH, Makuch RW, Reiss AL, Ment LR: Increased temporal lobe gyrification in preterm children. Neuropsychologia 2006;44:445–453.
- Tolsa CB, Zimine S, Warfield SK, Freschi M, Sancho Rossignol A, Lazeyras F, Hanquinet S, Pfizenmaier M, Huppi PS: Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction. Pediatr Res 2004;56:132–138.
- Ment LR, Peterson BS, Vohr B, Allan W, Schneider KC, Lacadie C, Katz KH, Maller-Kesselman J, Pugh K, Duncan CC, Makuch RW, Constable RT: Cortical recruitment patterns in children born prematurely compared with control subjects during a passive listening functional magnetic resonance imaging task. J Pediatr 2006;149:490–498.
Stephen J. Sheinkopf, PhD
Brown Center for the Study of Children at Risk
Women and Infants Hospital of Rhode Island
101 Dudley Street, Providence, RI 02905 (USA)
Tel. +1 401 453 7637, Fax +1 401 453 7646, E-Mail email@example.com
Received: April 2, 2008
Accepted after revision: October 20, 2008
Published online: April 17, 2009
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 3, Number of References : 43
Vol. 31, No. 1-2, Year 2009 (Cover Date: April 2009)
Journal Editor: Levison S.W. (Newark, N.J.)
ISSN: 0378-5866 (Print), eISSN: 1421-9859 (Online)
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