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Vol. 124, No. 2, 2009
Issue release date: May 2009
Section title: Original Article
Cytogenet Genome Res 2009;124:128–131
(DOI:10.1159/000207517)

Interstitial telomeric sequences (ITSs) are not located at the exact evolutionary breakpoints in primates

Farré M. · Ponsà M. · Bosch M.
aDepartament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, bGenètica de la Conservació Animal, IRTA, Cabrils (Spain)

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: 12/4/2008
Published online: 5/5/2009

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Although their function has not yet been clearly elucidated, interstitial telomeric sequences (ITSs) have been cytogenetically associated with chromosomal reorganizations, fragile sites, and recombination hotspots. In this paper, we show that ITSs are not located at the exact evolutionary breakpoints of the inversions between human and chimpanzee and between human and rhesus macaque chromosomes. We proved that ITSs are not signs of repair in the breakpoints of the chromosome reorganizations analyzed. We found ITSs in the region (0.7–2.7 Mb) flanking one of the two breakpoints in all the inversions assessed. The presence of ITSs in those locations is not by chance. They are short (up to 7.83 repeats) and almost perfect (82.5–97.1% matches). The ITSs are conserved in the species compared, showing that they were present before the reorganizations occurred.


Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: 12/4/2008
Published online: 5/5/2009

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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