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Vol. 14, No. 3, 1999
Issue release date: May–June 1999
Fetal Diagn Ther 1999;14:185–189

Distribution of Neural Tube Defects as a Function of Maternal Weight:No Apparent Correlation

Feldman B. · Yaron Y. · Critchfield G. · Leon J. · O’Brien J.E. · Johnson M.P. · Evans M.I.
aDivision of Reproductive Genetics, Department of Obstetrics and Gynecology, Hutzel Hospital, bCenter for Molecular Medicine and Genetics, and cDepartment of Pathology, Wayne State University, Detroit, Mich., and dQuest Diagnostic, Teterboro, N.J., USA

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Objectives: Maternal nutritional deficiency is an important predisposing factor to congenital neural tube defects (NTDs). It was hypothesized that obese women may have an increased risk for NTDs. The aim of the present study was to address this question in a large cohort. Methods: A total of 72,915 consecutive cases of biochemical screening that had documented maternal weights and pregnancy outcomes were identified from the Quest Diagnostic Laboratories database. Patients were divided into five ranges of maternal weights, and the incidence of NTDs was calculated for each group. Based on the different definitions of maternal overweight, the data were also analyzed based on 2 groups only, obese and nonobese, using three cutoff points. Results: Seventy-nine pregnancies were complicated by NTDs (incidence of 1.08 per 1,000 pregnancies). Differences between maternal weights ranges were not found to be statistically significant (χ2 = 5.997, p = 0.19, power = 0.99). Differences between obese and nonobese mothers were not found to be statistically significant for all three analyses as well. Conclusions: Our present results do not support an association between maternal obesity and NTDs.

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  1. Shaw GM, Schaffer D, Valie EM, Morland K, Harris JA: Periconceptional vitamin use, dietary folate, and the occurrence of neural tube defects. Epidemiology 1995;6:219–226.
  2. MRC Vitamin Study Research Group: Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study. Lancet 1991;338:131–137.
  3. Hotzel D: Suboptimal nutritional status in obesity; in Somogyi JC, Trichopoulou A (eds): Scientific Evidence for Dietary Targets in Europe. Bibl Nutr Diet. Basel, Karger, 1986, vol 37, pp 36–41.
  4. Mills JL, Knopp RH, Simpson JL, Jovanovic Peterson L, Metzger BE, Homes LB: Lack of relation of increased malformation rates in infants of diabetic mothers to glycemic control during organogenesis. N Engl J Med 1988;318:671–676.
  5. Waller DK, Mills JL, Simpson JL, Cunningham GC, Conley MR, Lassman MR, Rhoads GG: Are obese women at high risk for producing malformed offspring? Am J Obstet Gynecol 1994;170:541–548.
  6. Shaw GM, Valie EM, Schaffer D: Risk of neural tube defect-affected pregnancies among obese women. JAMA 1996;275:1093–1096.
  7. Werler MM, Louik C, Shapiro S, Mitchell AA: Prepregnant weight in relation to risk of neural tube defects. JAMA 1996;275:1089–1092.
  8. Wald N, Cuckle H, Boreham J, Terzian E, Redman C: The effect of maternal weight on maternal serum alpha-fetoprotein levels. Br J Obstet Gynaecol 1981;88:1094–1096.

    External Resources

  9. Haddow JE, Smith DE, Sever J: Effect of maternal weight on maternal serum α-fetoprotein. Br J Obstet Gynaecol 1982;89:93.

    External Resources

  10. Johnson AM, Palomaki GE, Haddow JE: The effect of adjusting maternal serum α-fetoprotein levels for maternal weight in pregnancies with fetal open spina bifida. Am J Obstet Gynecol 1990;163:163–169.
  11. Haddow JE, Palomaki GE: Is maternal obesity a risk factor for open neural tube defects? (letter to the editor). Am J Obstet Gynecol 1995;172:245–246.

    External Resources

  12. Leck I: Correlations of malformation frequency with environmental and genetic attributes in man; in Wilson JG, Fraser FC (eds): Handbook of Teratology. New York, Plenum Press, 1977, pp 241–324.
  13. Elwood JM, Little J, Elwood JH: Epidemiology and Control of Neural Tube Defects. Oxford, Oxford University Press, 1992.
  14. Smithells RW, Sheppard S, Schorah CJ: Vitamin deficiencies and neural tube defects. Arch Dis Child 1976;51:944–950.

    External Resources

  15. Laurence KM, James N, Miller MH, Tennant GB, Campbell H: Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural tube defects. BMJ 1981;282:1509–1511.
  16. Smithells RW, Sheppard S, Schorah CJ, Seller MJ, Nevin NC, Harris R, Read AP, Fielding DW: Apparent prevention of neural tube defects by periconceptional vitamin supplementation. Arch Dis Child 1981;56:911–918.

    External Resources

  17. Milunski A, Jick H, Jick SS, Bruell CL, MacLaughlin DS, Rothman KJ, Willet W: Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA 1989;262:2847–2852.
  18. Werler MM, Shapiro S, Mitchell AA: Periconceptional folic acid exposure and risk of occurrent neural tube defects. JAMA 1993;269:1257–1261.
  19. Mulinare J, Cordero JF, Erickson JD, Berry RJ: Periconceptional use of multivitamins and the occurrence of neural tube defects. JAMA 1988;260:3141–3145.
  20. Czeizel AE, Dudas I: Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation. N Engl J Med 1992;327:1832–1835.
  21. Holmes LB: Spina bifida: Anticonvulsants and other maternal influences. Ciba Found Symp 1994;181:232.
  22. Milunski A, Ulcickas M, Rothman KJ, Willet W, Jick SS, Jick H: Maternal heat exposure and neural tube defects. JAMA 1992;268:882–885.
  23. Wolfe HM: High prepregnancy body-mass index – A maternal-fetal risk factor. N Engl J Med 1998;338:191–192.
  24. Martin L, Chavez GF, Adams MJ Jr, Mason EE, Hanson JW, Haddow JE, Currier RW: Gastric bypass surgery as maternal risk factor for neural tube defects. Lancet 1988;8586:640–641.
  25. Robert E, Francannet C, Shaw GM: Neural tube defects and maternal weight reduction in early pregancy. Reprod Toxicol 1995;9:57–59.

    External Resources

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