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Vol. 71, No. 3, 2009
Issue release date: July 2009
Section title: Original Paper
ORL 2009;71:129–134
(DOI:10.1159/000209313)

Cervical Lymph Node Metastasis Model of Pyriform Sinus Carcinoma

Shen N. · Wu H. · Xu X. · Wang J. · Hoffman M.R. · Rieves A.L. · Zhou L.
aDepartment of Otolaryngology, ZhongShan Hospital, and bDepartment of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China; cDepartment of Surgery, Division of Otolaryngology – Head and Neck Surgery, University of Wisconsin and Madison School of Medicine and Public Health, Madison, Wisc., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/30/2008
Accepted: 1/26/2009
Published online: 1/24/2009

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL

Abstract

Objective: To establish a cervical lymph node metastasis model of pyriform sinus VX2 carcinoma and investigate its metastatic features. Methods: VX2 tumor tissue suspension was transplanted into the pyriform sinus submucosa of 15 rabbits under direct laryngoscopy. Rabbits were randomly placed into 1 of 3 groups, each comprised of 5 rabbits. Health evaluation and histopathological analysis were performed on days 14 (group 1), 21 (group 2), and 28 (group 3) after transplantation. Results: VX2 tumors were transplanted successfully in all rabbits. Dysphagia, weight loss, rhinorrhea, and dyspnea were observed 28 days after transplantation. Deep cervical lymph node metastasis occurred in all rabbits at all time points. The rate of submandibular lymph node metastasis was 60% in group 1, 80% in group 2, and 100% in group 3. The rate of paratracheal lymph node metastasis was 0% in group 1, 80% in group 2, and 100% in group 3. Conclusions: A model of metastatic pyriform sinus carcinoma was established. This model could be used in future studies evaluating diagnostic and treatment methods.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/30/2008
Accepted: 1/26/2009
Published online: 1/24/2009

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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