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Vol. 82, No. 3, 2009
Issue release date: May 2009
Section title: Original Paper
Urol Int 2009;82:312–317
(DOI:10.1159/000209364)

Aurora-A/STK-15 Is Differentially Expressed in the Micropapillary Variant of Bladder Cancer

Compérat E. · Roupret M. · Conort P. · Chartier-Kastler E. · Bitker M.-O. · Richard F. · Capron F. · Haertig A. · Cussenot O. · Camparo P.
aService d’Anatomie et Cytologie Pathologique, Hôpital La Pitié Salpêtrière, and bService d’Urologie, Hôpital La Pitié Salpêtrière et Hôpital Tenon, CHU-Est, Université Pierre et Marie Curie, and cService d’Anatomie et Cytologie Pathologique, Hôpital des Instructions des Armées Val-de-Grâce, Paris, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/11/2008
Accepted: 11/4/2008
Published online: 5/11/2009

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Introduction: Micropapillary carcinoma (MPC) of the bladder is a rare and aggressive histologic variant of urothelial carcinoma (UC). At the time of presentation, most MPC are muscle invasive with frequent vascular invasion (VI). Our series explores protein expression of markers known to be indicators of poor clinical outcome and progression, trying to explain aggressiveness of MPC. Patients and Methods: 18 patients with MPC were reviewed. We explored protein expression of p53, MIB-1, Aurora-A and survivin in MPC and compared their expression to conventional urothelial carcinoma (CUC) of the same grade and stage. Results: Patients, aged 46–85 years, underwent transurethral resection or cystoprostatectomy for UC. MPC was either pure (39%) or only partially present (61%). 55% of the patients died. VI was seen in 95%. MPC displayed overexpression of p53 and MIB-1, Aurora-A and survivin. No statistically significant difference could be made with CUC except for Aurora-A (p = 0.03). Conclusions: This is the first study to explore different markers of bad clinical outcome in MPC. We suggest that Aurora-A via mechanisms implied into early steps of mitosis might play a role in aggressive clinical behavior of MPC.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/11/2008
Accepted: 11/4/2008
Published online: 5/11/2009

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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