Journal Mobile Options
Table of Contents
Vol. 6, No. 5, 1999
Issue release date: October 1999
Section title: Original Article · Originalarbeit
Forsch Komplementärmed 1999;6:256–260
(DOI:10.1159/000021260)

Prophylaktische Wirkungen von Propolis zur Immunstimulation: Eine klinische Pilotstudie

Brätter C. · Tregel M. · Liebenthal C. · Volk H.-D.
aBörner GmbH Berlin, bPharmakologische Forschungsgesellschaft Biopharm GmbH, Berlin, cInstitut für klinische Immunologie, Universitätsklinikum Charité, Berlin

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restriction apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 11/17/2004

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK

Abstract

Summary

Objective: The aim of this pilot investigation was to show the evidence of the prophylactic immunostimulating effectiveness caused by propolis. The immune response was determined by the measurement of the cytokine level in vivo and ex vivo (TNF-α, IL-6, IL-8). Study Design:In an open prospective monocentric study, test persons received Propolis XNP. Patients: 10 healthy test persons aged between 18 and 45 years, with normal weight and of either sex. Interventions:Probands received over 13 days 500 mg Propolis XNP (2 capsules) for peroral application in the morning. Main Outcome Measures: Significant changes of the investigated cytokine secretion capacity during and after the treatment of propolis compared to the situation without medication. Results:Although the cytokine plasma levels did not significantly change during the study, propolis led to a significant increase of both the spontaneous (TNF-α, p < 0.05; IL-6, p < 0.01; IL-8, p < 0.02; IL-1β, not detectable) and LPS(lipopolysaccaride)-induced (TNF-α, p < 0.001; IL-6, p < 0.02; IL-8, p < 0.0005; IL-1β, p < 0.05) cytokine secretion capacity following short-term ex vivo culture of peripheral blood leukocytes. Whereas the IL-6 secretion capacity further increased during the 13-day application, the IL-8 and TNF-α secretion reached a plateau after day 4 and the TNF-α secretion even decreased, but the level at day 13 was still significantly higher than at day 0. Conclusion: As the cytokine secretion capacity but not the cytokine plasma levels increased significantly during therapy, the prophylactic application of propolis led to a time dependent enhanced immune reactivity without undesired side effects.


Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 11/17/2004

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.