Cover

Food Factors for Health Promotion

Editor(s): Yoshikawa T. (Kyoto) 
Table of Contents
Vol. 61, No. , 2009
Section title: Life-style Related Diseases
Yoshikawa T (ed): Food Factors for Health Promotion. Forum Nutr. Basel, Karger, 2009, vol 61, pp 129–135
(DOI:10.1159/000212745)

Astaxanthin Protects Neuronal Cells against Oxidative Damage and Is a Potent Candidate for Brain Food

Liu X. · Osawa T.
Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Science, Nagoya University, Nagoya, Japan

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Article / Publication Details

First-Page Preview
Abstract of Life-style Related Diseases

Published online: 4/7/2009
Cover Date: 2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9097-6 (Print)
eISBN: 978-3-8055-9098-3 (Online)

Abstract

Astaxanthin (AST) is a powerful antioxidant that occurs naturally in a wide variety of living organisms. Based on the report claiming that AST could cross the brain-blood barrier, the aim of this study was to investigate the neuroprotective effect of AST by using an oxidative stress-induced neuronal cell damage system. The treatment with DHA hydroperoxide (DHA-OOH) or 6-hydroxydopamine (6-OHDA), either of which is a reactive oxygen species (ROS)-inducing neurotoxin, led to a significant decrease in viable dopaminergic SH-SY5Y cells by the MTT assay, whereas a significant protection was shown when the cells were pretreated with AST. Moreover, 100 nM AST pretreatment significantly inhibited intracellular ROS generation that occurred in either DHA-OOH- or 6-OHDA-treatedcells. The neuroprotective effect of AST is suggested to be dependent upon its antioxidant potential and mitochondria protection; therefore, it is strongly suggested that treatment with AST may be effective for oxidative stress-associated neurodegeneration and a potential candidate for natural brain food.


Article / Publication Details

First-Page Preview
Abstract of Life-style Related Diseases

Published online: 4/7/2009
Cover Date: 2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9097-6 (Print)
eISBN: 978-3-8055-9098-3 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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