Objective: Response to pegylated (PEG) interferon (IFN) and ribavirin is achieved only in 40–50% of patients infected with hepatitis C virus (HCV) of genotype 1 in high viral loads, which needs to be improved. Methods: In an open-label pilot study, fluvastatin (HMG-CoA reductase inhibitor), 20 mg daily, was given along with PEG-IFN/ribavirin to 21 patients with chronic hepatitis C. They were followed for HCV RNA in serum. Results: During treatment for 48 weeks, HCV RNA was lost from serum in 93% of the patients. In the 15 patients who received 48-week therapy, a sustained virological response (SVR) with loss of HCV RNA 24 weeks after completion was achieved in 10 (67%), including 7 of the 9 (78%) male and 3 of the 6 (50%) female patients. In the remaining 6 patients who received 72-week therapy, SVR was gained in 4 (67%), including 1 of the 2 male and 3 of the 4 female patients aged 56, 58 and 62 years, respectively. Conclusion: Fluvastatin could be used safely to increase the response to PEG-IFN and ribavirin, especially in aged women who respond poorly to combined PEG-IFN/ribavirin.
© 2009 S. Karger AG, Basel
- Hepatitis, chronic
- Virus, hepatitis C
- Interferon, pegylated
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Hitomi Sezaki, MD
Department of Hepatology, Toranomon Hospital
Tokyo 105-8470 (Japan)
Tel. +81 44 877 5111, Fax +81 44 860 1623, E-Mail firstname.lastname@example.org
Received: August 25, 2008
Accepted: March 5, 2009
Published online: April 17, 2009
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 1, Number of References : 48
Intervirology (International Journal of Basic and Medical Virology)
Vol. 52, No. 1, Year 2009 (Cover Date: May 2009)
Journal Editor: Liebert U.G. (Leipzig)
ISSN: 0300-5526 (Print), eISSN: 1423-0100 (Online)
For additional information: http://www.karger.com/INT
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