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Table of Contents
Vol. 43, No. 1-2, 1997
Issue release date: 1997
Section title: Original Paper
Gerontology 1997;43:26–43
(DOI:10.1159/000213834)

Cerebromicrovascular Pathology in Alzheimer’s Disease Compared to Normal Aging

de la Torre J.C.
Division of Neurosurgery, and Department of Physiology, University of New Mexico School of Medicine, Albuquerque, N.M., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/23/1995
Accepted: 1/29/1996
Published online: 4/15/2009

Number of Print Pages: 18
Number of Figures: 0
Number of Tables: 0

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER

Abstract

A growing amount of data using light and electron microscopy, immunocytochemistry, uptake of brain markers and metabolic studies suggest that the pathogenesis of Alzheimer’s disease may be due to impaired vascular delivery of nutrients to the brain. The bulk of this evidence indicates that cerebral capillary transport of glucose, oxygen and other vital nutrients is dysfunctional in Alzheimer brains due to abnormal nemo-dynamic flow patterns caused by structural deformities of the capillaries. Clinical disorders which can worsen cerebral blood flow, such as head injury, coronary artery disease, cerebrovas-cular ischemia or the presence of apolipoprotein E4 allele will increase the risk of Alzheimer’s dementia. By contrast, activities that increase cerebral blood flow during aging such as complex thinking patterns or the use of drugs to reduce vascular resistance, such as aspirin or NSAIDs, will reduce the risk or improve the status of Alzheimer’s disease. The production of neuritic plaques and neurofibrillary tangles may develop from the hypometabolic abnormalities caused by the impaired cerebromicrovasculature in Alzheimer brains. Such metabolic and cerebral blood flow changes are considerably less significant in age-matched control subjects. The major physiological, pathological and cognitive changes reported for Alzheimer’s disease appear to have a common denominator which is reflected by the physically distorted cerebromicrovessels and their inability to optimally deliver nutrients to the brain, a condition which ultimately disturbs neurono-glial homeo-stasis.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/23/1995
Accepted: 1/29/1996
Published online: 4/15/2009

Number of Print Pages: 18
Number of Figures: 0
Number of Tables: 0

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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