Coping with mild early life stress tends to make subsequent coping efforts more effective and therefore more likely to be used as a means of arousal regulation and resilience. Here we show that this developmental learning-like process of stress inoculation increases ventromedial prefrontal cortical volumes in peripubertal monkeys. Larger volumes do not reflect increased cortical thickness but instead represent surface area expansion of ventromedial prefrontal cortex. Expansion of ventromedial prefrontal cortex coincides with increased white matter myelination inferred from diffusion tensor magnetic resonance imaging. These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience.
© 2009 S. Karger AG, Basel
- Emotion regulation
- Cognitive control
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David M. Lyons
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Received: January 9, 2009
Accepted: January 9, 2009
Published online: June 17, 2009
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 1, Number of References : 63
Vol. 31, No. 4, Year 2009 (Cover Date: June 2009)
Journal Editor: Levison S.W. (Newark, N.J.)
ISSN: 0378-5866 (Print), eISSN: 1421-9859 (Online)
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