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Dev Neurosci 2009;31:293–299

Prefrontal Plasticity and Stress Inoculation-Induced Resilience

Katz M.a · Liu C.b · Schaer M.c, d · Parker K.J.a · Ottet M.-C.c · Epps A.a · Buckmaster C.L.a · Bammer R.b · Moseley M.E.b · Schatzberg A.F.a · Eliez S.c · Lyons D.M.a
Departments of aPsychiatry and bRadiology, Stanford University, Stanford, Calif., USA; cDivision of Child and Adolescent Psychiatry, Geneva University, Geneva, and dSignal Processing Institute, Swiss Federal Institute of Technology, Lausanne, Switzerland
email Corresponding Author

 goto top of outline Key Words

  • Emotion regulation
  • Cognitive control
  • Fear
  • Curiosity
  • Cortisol

 goto top of outline Abstract

Coping with mild early life stress tends to make subsequent coping efforts more effective and therefore more likely to be used as a means of arousal regulation and resilience. Here we show that this developmental learning-like process of stress inoculation increases ventromedial prefrontal cortical volumes in peripubertal monkeys. Larger volumes do not reflect increased cortical thickness but instead represent surface area expansion of ventromedial prefrontal cortex. Expansion of ventromedial prefrontal cortex coincides with increased white matter myelination inferred from diffusion tensor magnetic resonance imaging. These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience.

Copyright © 2009 S. Karger AG, Basel

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 goto top of outline Author Contacts

David M. Lyons
1201 Welch Rd
Stanford, CA 94305-5485 (USA)
Tel. +1 650 725 5931, Fax +1 650 498 7761, E-Mail dmlyons@stanford.edu

 goto top of outline Article Information

Received: January 9, 2009
Accepted: January 9, 2009
Published online: June 17, 2009
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 1, Number of References : 63

 goto top of outline Publication Details

Developmental Neuroscience

Vol. 31, No. 4, Year 2009 (Cover Date: June 2009)

Journal Editor: Levison S.W. (Newark, N.J.)
ISSN: 0378-5866 (Print), eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

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