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Vol. 42, No. 4, 2009
Issue release date: June 2009

Anomalous Subjective Experience and Psychosis Risk in Young Depressed Patients

Szily E. · Kéri S.
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Abstract

Background: Help-seeking young people often display depressive symptoms. In some patients, these symptoms may co-exist with clinically high-risk mental states for psychosis. The aim of this study was to determine differences in subjective experience and social perception in young depressed patients with and without psychosis risk. Methods: Participants were 68 young persons with major depressive disorder. Twenty-six patients also met the criteria of attenuated or brief limited intermittent psychotic symptoms according to the Comprehensive Assessment of At Risk Mental States (CAARMS) criteria. Subjective experiences were assessed with the Bonn Scale for the Assessment of Basic Symptoms (BSABS). Recognition of complex social emotions and mental states was assessed using the ‘Reading the Mind in the Eyes’ test. Results: Perplexity, self-disorder, and diminished affectivity significantly predicted psychosis risk. Depressed patients without psychosis risk displayed impaired recognition performance for negative social emotions, whereas patients with psychosis risk were also impaired in the recognition of cognitive expressions. In the high-risk group, self-disorder was associated with impaired recognition of facial expressions. Conclusions: These results suggest that anomalous subjective experience and impaired recognition of complex emotions may differentiate between young depressed patients with and without psychosis risk.



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References

  1. Yung AR, Phillips L, McGorry PD: Treating schizophrenia in the prodromal phase. London, Taylor & Francis, 2004.
  2. Rosen JL, Miller TJ, D’Andrea JT, McGlashan TH, Woods SW: Comorbid diagnoses in patients meeting criteria for the schizophrenia prodrome. Schizophr Res 2006;85:124–131.
  3. Yung AR, Buckby JA, Cosgrave EM, et al: Association between psychotic experiences and depression in a clinical sample over 6 months. Schizophr Res 2007;91:246–253.
  4. Häfner H, Maurer K: Early detection of schizophrenia: current evidence and future perspectives. World Psychiatry 2006;5:130–138.

    External Resources

  5. Schultze-Lutter F, Ruhrmann S, Picker H, von Reventlow HG, Brockhaus-Dumke A, Klosterkötter J: Basic symptoms in early psychotic and depressive disorders. Br J Psychiatry Suppl 2007;51:s31–s37.
  6. Olsen KA, Rosenbaum B: Prospective investigations of the prodromal state of schizophrenia: review of studies. Acta Psychiatr Scand 2006;113:247–272.
  7. Keshavan MS, Amirsadri A: Early intervention in schizophrenia: current and future perspectives. Curr Psychiatry Report 2007;9:325–328.
  8. Klosterkötter J, Schultze-Lutter F, Ruhrmann S: Kraepelin and psychotic prodromal conditions. Eur Arch Psychiatry Clin Neurosci 2008;258:74–84.
  9. Salokangas RK, McGlashan TH: Early detection and intervention of psychosis: a review. Nord J Psychiatry 2008;62:92–105.
  10. Bechdolf A, Schultze-Lutter F, Klosterkötter J: Self-experienced vulnerability, prodromal symptoms and coping strategies preceding schizophrenia and depressive relapses. Eur Psychiatry 2002;17:384–393.
  11. Gross G, Huber G, Klosterkötter J: Bonn Scale for the Assessment of Basic Symptoms – BSABS. Berlin, Springer, 1987.
  12. Klosterkötter J, Hellmich M, Steinmeyer EM, et al: Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry 2001;58:158–164.
  13. Rubino IA, Ciani N: A multivariate exploration of basic symptoms. Psychopathology 2002;35:267–271.
  14. Vollmer-Larsen A, Handest P, Parnas J: Reliability of measuring anomalous experience: the Bonn Scale for the Assessment of Basic Symptoms. Psychopathology 2007;40:345–348.
  15. Simon AE, Dvorsky DN, Boesch J, et al: Defining subjects at risk for psychosis: a comparison of two approaches. Schizophr Res 2006;81:83–90.
  16. Pukrop R, Schultze-Lutter F, Ruhrmann S, et al: Neurocognitive functioning in subjects at risk for a first episode of psychosis compared with first- and multiple-episode schizophrenia. J Clin Exp Neuropsychol 2006;28:1388–1407.
  17. Schultze-Lutter F, Klosterkötter J, Picker H, Steinmeyer EH, Ruhrmann S: Predicting first episode psychosis by basic symptom criteria. Clin Neuropsychiatry 2007;4:11–22.
  18. Baron-Cohen S, Wheelwright S, Hill J, et al: The ‘Reading the Mind in the Eyes’ Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry 2001;42:241–251.
  19. Brune M: ‘Theory of mind’ in schizophrenia: a review of the literature. Schizophr Bull 2005;31:21–42.
  20. Irani F, Platek SM, Panyavin IS, et al: Self-face recognition and theory of mind in patients with schizophrenia and first-degree relatives. Schizophr Res 2006;88:151–160.
  21. Kettle JW, O’Brien-Simpson L, Allen NB: Impaired theory of mind in first-episode schizophrenia: comparison with community, university and depressed controls. Schizophr Res 2008;99:96–102.
  22. Pinkham AE, Penn DL, Perkins DO, Graham KA, Siegel M: Emotion perception and social skill over the course of psychosis: a comparison of individuals ‘at-risk’ for psychosis and individuals with early and chronic schizophrenia spectrum illness. Cogn Neuropsychiatry 2007;12:198–212.
  23. Sheehan DV, Lecrubier Y, Sheehan KH, et al: The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998;59(suppl 20):22–33.
  24. First MB, Spitzer R L, Gibbon M, Williams JBW: Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV). Washington, American Psychiatric Press, 1996.
  25. Cirino PT, Chin CE, Sevcik RA, Wolf M, Lovett M, Morris RD: Measuring socioeconomic status: reliability and preliminary validity for different approaches. Assessment 2002;9:145–155.
  26. Wechsler D: Wechsler Adult Intelligence Scale – Revised Manual. New York, Psychological Corporation, 1981.
  27. Parnas J, Handest P, Saebye D, et al: Anomalies of subjective experience in schizophrenia and psychotic bipolar illness. Acta Psychiatr Scand 2003;108:126–133.
  28. Shaw P, Bramham J, Lawrence EJ, et al: Differential effects of lesions of the amygdala and prefrontal cortex on recognizing facial expressions of complex emotions. J Cogn Neurosci 2005;17:1410–1419.
  29. Lee L, Harkness KL, Sabbagh MA, et al: Mental state decoding abilities in clinical depression. J Affect Disord 2005;86:247–258.
  30. Kington JM, Jones LA, Watt AA, Hopkin EJ, Williams J: Impaired eye expression recognition in schizophrenia. J Psychiatr Res 2000;34:341–347.
  31. Kelemen O, Erdélyi R, Pataki I, et al: Theory of mind and motion perception in schizophrenia. Neuropsychology 2005;19:494–500.
  32. Marjoram D, Miller P, McIntosh AM, Cunningham Owens DG, Johnstone EC, Lawrie S: A neuropsychological investigation into ‘Theory of Mind’ and enhanced risk of schizophrenia. Psychiatry Res 2006;144:29–37.
  33. Marjoram D, Job DE, Whalley HC, et al: A visual joke fMRI investigation into Theory of Mind and enhanced risk of schizophrenia. Neuroimage 2006;31:1850–1858.
  34. Seiferth NY, Pauly K, Habel U, et al: Increased neural response related to neutral faces in individuals at risk for psychosis. Neuroimage 2008;40:289–297.
  35. Chung YS, Kang DH, Shin NY, Yoo SY, Kwon JS: Deficit of theory of mind in individuals at ultra-high-risk for schizophrenia. Schizophr Res 2008;99:111–118.
  36. Couture SM, Penn DL, Addington J, Woods SW, Perkins DO: Assessment of social judgments and complex mental states in the early phases of psychosis. Schizophr Res 2008;100:237–241.
  37. Klosterkötter J, Ebel H, Schultze-Lutter F, et al: Diagnostic validity of basic symptoms. Eur Arch Psychiatry Clin Neurosci 1996;246:147–154.
  38. Resch F, Koch E, Möhler E, Parzer P, Brunner R: Early detection of psychotic disorders in adolescents: specificity of basic symptoms in psychiatric patient samples. Psychopathology 2002;35:259–266.
  39. Häfner H, Maurer K, Trendler G, an der Heiden W, Schmidt M: The early course of schizophrenia and depression. Eur Arch Psychiatry Clin Neurosci 2005;255:167–173.
  40. Nelson B, Yung AR, Bechdolf A, McGorry PD: The phenomenological critique and self-disturbance: implications for ultra-high risk (‘prodrome’) research. Schizophr Bull 2008;34:381–392.


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