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Ann Nutr Metab 2009;54:208–217

Influence of Early Nutritional Components on the Development of Murine Autoimmune Diabetes

Mueller D.B.a · Koczwara K.a · Mueller A.S.c, d · Pallauf J.c · Ziegler A.-G.a, b · Bonifacio E.e
aInstitut für Diabetesforschung der Forschergruppe Diabetes e.V. am Helmholtz Zentrum München and bKlinik für Endokrinologie, Diabetologie und Suchtmedizin, Klinikum Schwabing, Städt. Klinikum München GmbH, München, cInstitute of Animal Nutrition and Nutritional Physiology, University Giessen, Giessen, dInstitute of Agricultural and Nutritional Sciences, Preventive Nutrition Group, University Halle, Halle/Saale, and eCenter for Regenerative Therapies Dresden, Dresden University of Technology, Dresden, Germany
email Corresponding Author

 goto top of outline Key Words

  • Type 1 diabetes
  • Autoimmunity
  • NOD mice
  • Diet
  • Prevention
  • Gluten
  • Casein

 goto top of outline Abstract

Background/Aims: Infant diet is suggested to modify autoimmune diabetes risk. The aim of this study was to determine whether infant food components affect diabetes development in the nonobese autoimmune diabetes (NOD) mouse. Methods: A basal low-diabetogenic diet was identified by feeding litter-matched female NOD mice standardized diets with and without casein and wheat proteins after weaning. In subsequent trials, basal diet with supplements of wheat (5, 10 and 30%), gluten, wheat globulin/albumin, corn (5%), potato (5%), apple (5%) or carrot (5%) was fed to litter-matched female NOD mice after weaning. Mice were followed for diabetes development and insulin autoantibodies. Results: A casein- and wheat-free diet was associated with the lowest rate of diabetes development (37% by age 25 weeks). Increased diabetes rates were observed when the basal diet was supplemented with 5% wheat (71% by age 25 weeks; p = 0.023) and 5% corn (57% by age 25 weeks; p = 0.05). Increasing wheat concentrations returned diabetes development to that in basal diet-fed mice. Other food supplements had no or minimal effects on diabetes development. Conclusions: Early supplementation of a basal low-diabetogenic diet with low concentrations of the cereals wheat or corn is associated with a moderate increase in the rate of diabetes. Removal of cereals, however, does not abrogate diabetes development in NOD mice.

Copyright © 2009 S. Karger AG, Basel

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    External Resources

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 goto top of outline Author Contacts

Dr. Kerstin Koczwara
Institut für Diabetesforschung am Helmholtz Zentrum München
Ingolstädter Landstrasse 1, DE–85764 Neuherberg (Germany)
Tel. +49 89 31 87 39 06, Fax +49 89 30 81 733

 goto top of outline Article Information

Received: August 26, 2008
Accepted after revision: March 17, 2009
Published online: May 27, 2009
Number of Print Pages : 10
Number of Figures : 4, Number of Tables : 3, Number of References : 28

 goto top of outline Publication Details

Annals of Nutrition and Metabolism (Journal of Nutrition, Metabolic Diseases and Dietetics)

Vol. 54, No. 3, Year 2009 (Cover Date: August 2009)

Journal Editor: Elmadfa I. (Vienna)
ISSN: 0250-6807 (Print), eISSN: 1421-9697 (Online)

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