Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Cell-Cell Adhesion in the Prelaminar Region of the Optic Nerve Head: A Possible Target for Ionic Stress

Carreras F.J.a · Porcel D.c · Alaminos M.b · Garzón I.b
Departments of aSurgery (Ophthalmology) and bCellular Biology, Faculty of Medicine, and cCenter of Scientific Instrumentation, University of Granada, Granada, Spain Ophthalmic Res 2009;42:106–111 (DOI:10.1159/000225964)


Purpose: This paper aims to study the anterior surface of the optic nerve in relation to its ability to support a source of stress acting from the vitreous cavity. The intercellular junctions of the lining astrocytes mediated by cellular adhesion molecules (CAMs) may be the main targets for ionic stress. Methods: The optic nerve of the domestic pig was prepared for light, confocal laser and transmission electron microscopy. Immunostaining was performed for antibodies against glial fibrillary acidic protein, neural cadherin (N-cadherin) and neural CAM (N-CAM). Results: Only 1 type of intercellular junction was found among the bordering astrocytes, which was characterized as a zonula adherens. Unions between lining cells showed a positive immunogold effect and immunofluorescence against N-cadherin in the zonula adherens and membrane apposition. N-CAM was also present in areas of nonjunctional cellular adhesion. Conclusion: The stability of intercellular junctions of the nerve-vitreous boundary is sensitive to altered concentrations of Ca2+. Since aqueous humor has half the Ca2+ concentration of plasma, any contact of aqueous humor with the optic nerve head can interfere with the ionic concentration of calcium in the extracellular spaces. This mechanism may contribute to age-related changes and some types of glaucoma.


Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50