The incidence of acute kidney injury (AKI) formerly referred to as acute renal failure (ARF) is increasing to epidemic proportions. Development of AKI portends excessive morbidity and mortality. AKI is associated with prolonged hospital stay, increased healthcare costs and high mortality especially in critically ill patients. The mortality rate has remained largely unchanged for many decades. Delay in the diagnosis of AKI using conventional biomarkers like urine output and serum creatinine has been one of the important obstacles in applying effective early interventions. Several new biomarkers are being evaluated in a quest for early diagnosis of AKI, among which neutrophil gelatinase-associated lipocalin (NGAL) appears to be one of the most promising. This review summarizes the recent literature on these biomarkers.
© 2009 S. Karger AG, Basel
- Acute renal failure
- Acute kidney injury
- Acute Kidney Injury Network (AKIN)
- RIFLE Classification
- Neutrophil gelatinase-associated lipocalin
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- Devarajan P: Neutrophil gelatinase-associated lipocalin – an emerging troponin for kidney injury. Nephrol Dial Transplant 2008;23:3737–3743.
Dr. Dinna N. Cruz
Nephrology Dialysis and Transplantation, San Bortolo Hospital
Via Rodolfi, 37, IT–36100 Vicenza (Italy)
Tel. +39 0444 753 650, Fax +39 0444 753 949
S.S. Soni is supported by a fellowship grant from the International Society of Nephrology.
Published online: July 8, 2009
Number of Print Pages : 10
Number of Figures : 0, Number of Tables : 3, Number of References : 93
Vol. 28, No. 3, Year 2009 (Cover Date: October 2009)
Journal Editor: Ronco C. (Vicenza)
ISSN: 0253-5068 (Print), eISSN: 1421-9735 (Online)
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