Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot Password? Reset your password

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login (Shibboleth)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Table of Contents
Vol. 27, No. 6, 2009
Issue release date: July 2009
Section title: Original Research Article
Free Access
Dement Geriatr Cogn Disord 2009;27:564–571

Cognitive and Noncognitive Neurological Features of Young-Onset Dementia

Kelley B.J. · Boeve B.F. · Josephs K.A.
Department of Neurology, Mayo Clinic, Rochester, Minn., USA
email Corresponding Author

Brendan J. Kelley, MD

Department of Neurology, University of Cincinnati

260 Stetson Street, Suite 2300

Cincinnati, OH 45267 (USA)

Tel. +1 513 558 5501, Fax +1 513 558 4305, E-Mail kelleyb3@uc.edu


  1. Kelley BJ, Boeve BF, Josephs KA: Young-onset dementia: demographic and etiologic characteristics of 235 patients. Arch Neurol 2008;65:1502–1508.
  2. Licht EA, McMurtray AM, Saul RE, Mendez MF: Cognitive differences between early- and late-onset Alzheimer’s disease. Am J Alzheimers Dis Other Demen 2007;22: 218–222.
  3. Appleby BS, Appleby KK, Rabins PV: Does the presentation of Creutzfeldt-Jakob disease vary by age or presumed etiology? A meta-analysis of the past 10 years. J Neuropsychiatry Clin Neurosci 2007;19:428–435.
  4. Corato M, Cereda C, Cova E, Ferrarese C, Ceroni M: Young-onset CJD: age and disease phenotype in variant and sporadic forms. Funct Neurol 2006;21:211–215.
  5. Members of the Department of Neurology MC: Clinical Examinations in Neurology, ed 6. St. Louis, Mosby Year Book, 1998.
  6. Kelley BJ, Boeve BF, Josephs KA: Rapidly progressive young-onset dementia. Cogn Behav Neurol 2009;22:22–27.
  7. Woodburn KJ, Johnstone EC: Early-onset dementia in Lothian, Scotland: an analysis of clinical features and patterns of decline. Health Bull (Edinb) 1999;57:384–392.
  8. Harvey RJ: Young Onset Dementia: Epidemiology, Clinical Symptoms, Family Burden, Support and Outcome. London, Dementia Research Group, Imperial College School of Medicine, 1998, pp 1–145.
  9. Lapid MI, Rummans TA: Evaluation and management of geriatric depression in primary care. Mayo Clin Proc 2003;78:1423–1429.
  10. Fujihara S, Brucki SM, Rocha MS, Carvalho AA, Piccolo AC: Prevalence of presenile dementia in a tertiary outpatient clinic. Arq Neuropsiquiatr 2004;62:592–595.
  11. Harvey RJ, Skelton-Robinson M, Rossor MN: The prevalence and causes of dementia in people under the age of 65 years. J Neurol Neurosurg Psychiatry 2003;74:1206–1209.
  12. McMurtray A, Clark DG, Christine D, Mendez MF: Early-onset dementia: frequency and causes compared to late-onset dementia. Dement Geriatr Cogn Disord 2006;21:59–64.
  13. Newens AJ, Forster DP, Kay DW: Referral patterns and diagnosis in presenile Alzheimer’s disease: implications for general practice. Br J Gen Pract 1994;44:405–407.
  14. Panegyres PK, Frencham K: Course and causes of suspected dementia in young adults: a longitudinal study. Am J Alzheimers Dis Other Demen 2007;22:48–56.
  15. Treves T, Korczyn AD, Zilber N, Kahana E, Leibowitz Y, Alter M, Schoenberg BS: Presenile dementia in Israel. Arch Neurol 1986;43:26–29.
  16. Filley CM, Rollins YD, Alan Anderson C, Arciniegas DB, Howard KL, Murrell JR, Boyer PJ, Kleinschmidt-Demasters BK, Ghetti B: The genetics of very early onset Alzheimer disease. Cogn Behav Neurol 2007;20:149–156.
  17. Filley CM: White matter and behavioral neurology. Ann NY Acad Sci 2005;1064:162–183.
  18. Guo Y, Guo Z, Chen L, Zhang J, Wang W, Liu X, Ren H, Gao S: Clinical, pathologic and genetic studies on mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes. Chin Med J 1997;110:851–855.
  19. Hodges JR, Davies RR, Xuereb JH, Casey B, Broe M, Bak TH, Kril JJ, Halliday GM: Clinicopathological correlates in frontotemporal dementia. Ann Neurol 2004;56:399–406.
  20. Mendez MF: The accurate diagnosis of early-onset dementia. Int J Psychiatr Med 2006;36:401–412.
  21. Shinagawa S, Ikeda M, Toyota Y, Matsumoto T, Matsumoto N, Mori T, Ishikawa T, Fukuhara R, Komori K, Hokoishi K, Tanabe H: Frequency and clinical characteristics of early-onset dementia in consecutive patients in a memory clinic. Dement Geriatr Cogn Disord 2007;24:42–47.