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T2*-Weighted MRI versus Oxygen Extraction Fraction PET in Acute Stroke

Donswijk M.L.a · Jones P.S.a · Guadagno J.V.a · Carpenter T.A.b · Moustafa R.R.a · Fryer T.D.b · Aigbirhio F.I.b · Warburton E.A.c · Baron J.C.a
aStroke Research Group and bWolfson Brain Imaging Centre, Department of Clinical Neurosciences and cStroke Unit, Department of Medicine, University of Cambridge, Cambridge, UK Cerebrovasc Dis 2009;28:306–313 (DOI:10.1159/000229017)


Background: Mapping high oxygen extraction fraction (OEF) in acute stroke is of considerable interest to depict the at-risk tissue. Being sensitive to deoxyhemoglobin, T2*-weighted MRI has been suggested as a potential marker of high OEF. Methods: We compared T2*-weighted images from pre-contrast arrival perfusion scans against quantitative positron emission tomography in 5 patients studied 7–21 h after onset of carotid territory stroke. OEF and T2* signal were obtained in the voxels with significantly high OEF. Results: All patients showed increased OEF. No significant relationship between OEF and T2*-weighted signal was found either within or between subjects. Conclusion: We found no indication that T2*-weighted MRI in the way implemented in this investigation was sensitive to high OEF in acute stroke.


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