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Dement Geriatr Cogn Disord 2009;28:47–55

Risk Factors of Transition from Normal Cognition to Mild Cognitive Disorder: The PATH through Life Study

Cherbuin N.a · Reglade-Meslin C.a · Kumar R.a, b · Jacomb P.a · Easteal S.c · Christensen H.a · Sachdev P.d, e · Anstey K.J.a
aCentre for Mental Health Research, bDepartment of Psychological Medicine, and cJohn Curtin School of Medical Research, Australian National University, Canberra, A.C.T., and dSchool of Psychiatry, University of New South Wales, and eNeuropsychiatric Institute, Sydney, N.S.W., Australia
email Corresponding Author

 goto top of outline Key Words

  • Mild cognitive impairment
  • Alcohol
  • Hypertension
  • BMI
  • Depression

 goto top of outline Abstract

Aims: The aim of this study was to identify physical and mental health and lifestyle predictors of transition from normal cognition to mild cognitive disorder (MCD). Methods: A total of 2,082 individuals, aged 60–64 years, were assessed at 2 time-points 4 years apart for mild cognitive impairment (MCI) and other MCDs. Results: The main predictors of conversion to MCI and to other mild cognitive disorders were past alcohol intake, current anxiety and depression medication, increased systolic blood pressure, and past smoking. Conclusion: Participants with a history of smoking or harmful alcohol consumption, hypertension, or who took medication for anxiety or depression were at increased risk of transitioning to MCI or any MCD. Strategies targeted at managing the above risk factors may have benefits in preventing mild cognitive decline in relatively healthy middle-aged individuals living in the community.

Copyright © 2009 S. Karger AG, Basel

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 goto top of outline Author Contacts

Nicolas Cherbuin
Centre for Mental Health Research, Building 63
Australian National University
Canberra, A.C.T. 0200 (Australia)
Tel. +61 2 6125 3858, Fax +61 2 6125 0733, E-Mail

 goto top of outline Article Information

Accepted: May 15, 2009
Published online: July 23, 2009
Number of Print Pages : 9
Number of Figures : 1, Number of Tables : 4, Number of References : 44

 goto top of outline Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 28, No. 1, Year 2009 (Cover Date: August 2009)

Journal Editor: Chan-Palay V. (New York, N.Y.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)

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