- Metastatic urothelial cancer
- Second-line chemotherapy
- Transitional cell carcinoma
Background: Despite high response rates with front-line platinum-based therapies, 80% of patients with metastatic urothelial cancer progress. Multiple agents and couplets have been investigated, but no standard second-line regimen exists. We conducted a phase II study to evaluate the efficacy and safety of docetaxel and oxaliplatin in metastatic urothelial cancer patients who had received prior platinum therapy. Patients and Methods: Patients with metastatic urothelial cancer, who had disease progression after platinum therapy, were treated with docetaxel 75 mg/m2 and oxaliplatin 85 mg/m2 every 3 weeks until disease progression or intolerable toxicity. Results: Between November 2004 and September 2005, 11 patients were enrolled. All patients had low or intermediate Bajorin risk. The median number of cycles administered was 2 (range 2–8). One patient achieved near complete response. Three patients experienced disease stabilization, resulting in a disease-control rate of 36%. Median overall survival was 7 months. The most common toxicities were fatigue and anemia (50%). Conclusion: Second-line docetaxel and oxaliplatin in metastatic urothelial cancer is safe and tolerable but did not achieve an appreciable response rate.
Copyright © 2009 S. Karger AG, Basel
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Sandy Srinivas, MD
Department of Medical Oncology, Stanford Advanced Medicine Center
875 Blake Wilbur Drive
Stanford, CA 94305-1205 (USA)
Tel. +1 650 725 2078, Fax +1 650 736 1640, E-Mail email@example.com
Received: January 27, 2009
Accepted after revision: April 20, 2009
Published online: July 27, 2009
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 2, Number of References : 29
Chemotherapy (International Journal of Experimental and Clinical Chemotherapy)
Vol. 55, No. 5, Year 2009 (Cover Date: September 2009)
Journal Editor: Sörgel F. (Nürnberg-Heroldsberg)
ISSN: 0009-3157 (Print), eISSN: 1421-9794 (Online)
For additional information: http://www.karger.com/CHE
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