Vol. 31, No. 5, 2009
Issue release date: September 2009
Free Access
Dev Neurosci 2009;31:403–411
Original Paper
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Erythropoietin Sustains Cognitive Function and Brain Volume after Neonatal Stroke

Gonzalez F.F.a · Abel R.d, e · Almli C.R.d–f · Mu D.b, g · Wendland M.c · Ferriero D.M.a, b
Departments of aPediatrics, bNeurology and cRadiology, University of California, San Francisco, Calif., dDepartmental Neuropsychobiology Laboratory, eProgram in Occupational Therapy, and fDepartment of Neurology, Washington University School of Medicine, St. Louis, Mo., USA; gDepartment of Pediatrics, West China Second Hospital, Sichuan University, Chengdu, China
email Corresponding Author

 goto top of outline Key Words

  • Neonatal hypoxic-ischemic injury
  • Neonatal brain injury
  • Stroke
  • Cognitive function

 goto top of outline Abstract

Neonatal stroke leads to mortality and severe morbidity, but there currently is no effective treatment. Erythropoietin (EPO) promotes cytoprotection and neurogenesis in the short term following brain injury; however, long-term cognitive outcomes and optimal dosing regimens have not been clarified. We performed middle cerebral artery occlusion in postnatal day 10 rats, which were treated with either a single dose of EPO (5 U/g, i.p.) immediately upon reperfusion, or 3 doses of EPO (1 U/g, i.p. each) at 0 h, 24 h, and 7 days after injury. At 3 months after injury, rats treated with 3 doses of EPO did not differ from shams in the Morris water maze, and generally performed better than either rats treated with a single dose or vehicle-treated injured rats. These multiple-dose-treated rats also had increases in hemispheric volume and its subregions. These results suggest that additional, later doses of EPO may be required for cell repair, proliferation, and long-term incorporation into neural networks after neonatal brain injury.

Copyright © 2009 S. Karger AG, Basel

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 goto top of outline Author Contacts

Fernando F. Gonzalez, MD
Neonatal Brain Disorders Laboratory, University of California, San Francisco
521 Parnassus Avenue, C215
San Francisco, CA 94143-0663 (USA)
Tel. +1 415 502 5822, Fax +1 415 502 5821, E-Mail gonzalezf@peds.ucsf.edu

 goto top of outline Article Information

Received: October 2, 2008
Accepted: December 20, 2008
Published online: August 11, 2009
Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 1, Number of References : 57

 goto top of outline Publication Details

Developmental Neuroscience

Vol. 31, No. 5, Year 2009 (Cover Date: September 2009)

Journal Editor: Levison S.W. (Newark, N.J.)
ISSN: 0378-5866 (Print), eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

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