Neonatal stroke leads to mortality and severe morbidity, but there currently is no effective treatment. Erythropoietin (EPO) promotes cytoprotection and neurogenesis in the short term following brain injury; however, long-term cognitive outcomes and optimal dosing regimens have not been clarified. We performed middle cerebral artery occlusion in postnatal day 10 rats, which were treated with either a single dose of EPO (5 U/g, i.p.) immediately upon reperfusion, or 3 doses of EPO (1 U/g, i.p. each) at 0 h, 24 h, and 7 days after injury. At 3 months after injury, rats treated with 3 doses of EPO did not differ from shams in the Morris water maze, and generally performed better than either rats treated with a single dose or vehicle-treated injured rats. These multiple-dose-treated rats also had increases in hemispheric volume and its subregions. These results suggest that additional, later doses of EPO may be required for cell repair, proliferation, and long-term incorporation into neural networks after neonatal brain injury.
© 2009 S. Karger AG, Basel
- Neonatal hypoxic-ischemic injury
- Neonatal brain injury
- Cognitive function
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Fernando F. Gonzalez, MD
Neonatal Brain Disorders Laboratory, University of California, San Francisco
521 Parnassus Avenue, C215
San Francisco, CA 94143-0663 (USA)
Tel. +1 415 502 5822, Fax +1 415 502 5821, E-Mail firstname.lastname@example.org
Received: October 2, 2008
Accepted: December 20, 2008
Published online: August 11, 2009
Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 1, Number of References : 57
Vol. 31, No. 5, Year 2009 (Cover Date: September 2009)
Journal Editor: Levison S.W. (Newark, N.J.)
ISSN: 0378-5866 (Print), eISSN: 1421-9859 (Online)
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