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Vol. 88, No. 1-2, 1989
Issue release date: 1989
Int Arch Allergy Immunol 1989;88:34–39
(DOI:10.1159/000234744)

Involvement of Tumour Necrosis Factor and Other Cytokines in Immune-Mediated Vascular Pathology

Grau G.E. · Piguet P.-F. · Vassalli P. · Lambert P.-H.
World Health Organization Immunology Research and Training Centre, Department of Pathology, University of Geneva, Switzerland

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Abstract

Vascular endothelial cells are actively involved in coagulation and inflammation processes and appear to represent a important element in cell-mediated immune responses. In this paper, the possible role of endothelial cells as a target for immunopathological reactions was analyzed. Experimental neurovascular lesions were studied in a model of cerebral malaria, with particular attention to the role of cytokine interactions in vivo.



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