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Vol. 92, No. 1, 1990
Issue release date: 1990
Section title: Original Paper
Int Arch Allergy Immunol 1990;92:9–15
(DOI:10.1159/000235217)

Serum Antibodies Reactive with Saccharomyces cerevisiae in Inflammatory Bowel Disease: Is IgA Antibody a Marker for Crohn’s Disease?

Barnes R.M.R. · Allan S. · Taylor-Robinson C.H. · Finn R. · Johnson P.M.
Departments of aImmunology and bMedical Microbiology, University of Liverpool, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/12/1989
Accepted: 2/20/1990
Published online: 8/7/2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Sera from patients with Crohn’s disease (CD) and ulcerative colitis (UC) have been evaluated for antibodies reactive with Saccharomyces cerevisiae (anti-Sacc antibodies) using an enzyme-linked immunoassay (ELISA). IgG anti-Sacc antibodies were detected in 63% (25/40) of CD patients, compared with 15% (4/27) of UC patients (p <0.001) and 8% (5/60) healthy adult controls (p <0.001). Furthermore, the prevalence of detectable IgG anti-Sacc antibodies in adult patients with coeliac disease, dermatitis herpetiformis, irritable bowel syndrome or atopic eczema was not significantly different to controls. In comparison, the prevalence of detectable IgG anti-Escherichia coli antibodies was not significantly different between CD (75%) or UC (79%) patients. More particularly, elevated levels of serum IgA anti-Sacc antibodies were detected in 17/40 CD patients, but in none of the 27 UC patients. These data confirm that serum antibodies reactive with S. cerevisiae are strongly associated with CD and further show that serum IgA anti-Sacc antibodies may be specific for this disorder.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/12/1989
Accepted: 2/20/1990
Published online: 8/7/2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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