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Table of Contents
Vol. 22, No. 5, 2009
Issue release date: October 2009
Section title: Original Paper
Skin Pharmacol 2009;22:248–257
(DOI:10.1159/000235552)

Influence of Bathing or Washing on Skin Barrier Function in Newborns during the First Four Weeks of Life

Garcia Bartels N. · Mleczko A. · Schink T. · Proquitté H. · Wauer R.R. · Blume-Peytavi U.
aDepartment of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, bDepartment of Medical Statistics and Clinical Epidemiology, and cClinic for Neonatology CCM, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/27/2009
Accepted: 5/19/2009
Published online: 8/18/2009

Number of Print Pages: 10
Number of Figures: 6
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Background and Objectives: After birth, skin barrier function is in state of flux and at risk of dysfunction. In a prospective clinical study, we compared the effects of 2 standard cleansing procedures on skin barrier function in newborns. Methods: Fifty-seven healthy full-term neonates aged ≤48 h were randomly assigned to either a bathing group (group B; n = 29), who were bathed with clear water twice weekly, or to a washing group (group W; n = 28), who were washed with a washcloth moistened with clear water twice weekly. Transepidermal water loss (TEWL), skin pH, stratum corneum hydration (SCH) and sebum production were measured at days 2, 7 and 28 of life on the forehead, abdomen, upper leg and buttock. Results: Group B showed significantly lower TEWL on the buttock and higher SCH on the abdomen and forehead compared to group W at day 28. Conclusions: Both skin care regimens do not harm the adaptation of the skin barrier in healthy neonates within the first 4 weeks of life. Skin barrier function differentiates after birth in a regionally specific fashion.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/27/2009
Accepted: 5/19/2009
Published online: 8/18/2009

Number of Print Pages: 10
Number of Figures: 6
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.