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Vol. 2, No. 3, 2009
Issue release date: October 2009
Section title: Minireview
J Nutrigenet Nutrigenomics 2009;2:119–128
(DOI:10.1159/000235559)

FADS Gene Cluster Polymorphisms: Important Modulators of Fatty Acid Levels and Their Impact on Atopic Diseases

Lattka E. · Illig T. · Heinrich J. · Koletzko B.
aInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, and bDepartment of Pediatrics, Dr. von Hauner Children’s Hospital, University of Munich, Munich, Germany

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Article / Publication Details

First-Page Preview
Abstract of Minireview

Published online: 9/23/2009

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 1

ISSN: 1661-6499 (Print)
eISSN: 1661-6758 (Online)

For additional information: http://www.karger.com/JNN

Abstract

Long-chain polyunsaturated fatty acids (LC-PUFAs) play an important role in several physiological processes and their concentration in phospholipids has been associated with several complex diseases, such as atopic disease. The level and composition of LC-PUFAs in the human body is highly dependent on their intake in the diet or on the intake of fatty acid precursors, which are endogenously elongated and desaturated to physiologically active LC-PUFAs. The most important enzymes in this reaction cascade are the Δ5 and Δ6 desaturase. Several studies in the last few years have revealed that single nucleotide polymorphisms (SNPs) in the 2 desaturase encoding genes (FADS1 and FADS2) are highly associated with the concentration of ω–6 and ω–3 fatty acids, showing that beside nutrition, genetic factors also play an important role in the regulation of LC-PUFAs. This review focuses on current knowledge of the impact of genetic polymorphisms on LC-PUFA metabolism and on their potential role in the development of atopic diseases.


Article / Publication Details

First-Page Preview
Abstract of Minireview

Published online: 9/23/2009

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 1

ISSN: 1661-6499 (Print)
eISSN: 1661-6758 (Online)

For additional information: http://www.karger.com/JNN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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