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Vol. 102, No. 1, 1993
Issue release date: 1993
Section title: Original Paper
Int Arch Allergy Immunol 1993;102:33–45
(DOI:10.1159/000236548)

Ultrastructural Identification of Exocytosis of Granules from Human Gut Eosinophils in vivo

Dvorak A.M. · Onderdonk A.B. · McLeod R.S. · Monahan-Earley R.A. · Antonioli D.A. · Cullen J. · Blair J.E. · Cisneros R. · Letourneau L. · Morgan E. · Silen W. · Cohen Z.
aHarvard Digestive Disease Center and Departments of bPathology and cSurgery, Beth Israel Hospital and Harvard Medical School, Boston, Mass., USA; Departments of dSurgery and eMedicine, Mount Sinai Hospital, fDepartment of Pathology, Toronto General Hospital, Toronto, Canada; gDepartment of Pathology, Brigham & Women’s Hospital, Boston, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 9/3/2009

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Twenty-two percent of 117 biopsies of human intestinal tissues had ultrastructural images of classical regulated secretion from eosinophils in vivo i.e. eosinophil granule extrusion (EGE). Replicate intestinal biopsies that were positive for bacteria had EGE more often than not (p < 0.05); 77% of the isolates were Staphylococci. Some of the intestinal biopsies also had damaged nerves; all that had EGE and damaged enteric nerves also had positive bacterial cultures. The EGE that we observed could not account for all enteric nerve damage, suggesting multifactorial mechanisms for nerve damage in gut tissues. Among the possibilities are release of neurotoxic eosinophil granule proteins by an alternate secretory route, i.e., piecemeal degranulation, direct toxicity of tissue invasive bacteria and/or damaged nerves of unknown etiology such as those that are regularly present in uninvolved tissues of patients with Crohn’s disease.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 9/3/2009

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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