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Vol. 103, No. 1, 1994
Issue release date: 1994
Section title: Original Paper
Int Arch Allergy Immunol 1994;103:79–87
(DOI:10.1159/000236609)

Mode of Action of a Topical Steroid on Immediate Phase Reaction After Antigen Challenge and Nonspecific Nasal Hyperreactivity in Nasal Allergy

Konno A. · Yamakoshi T. · Terada N. · Fujita Y.
aDepartment of Otorhinolaryngology, School of Medicine, Chiba University, Chiba; bDepartment of Otorhinolaryngology, Akita University, School of Medicine, Akita, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 9/3/2009

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

This study compared the effects of 2-week administration of a topical steroid (fluticasone propionate [FP] 100 μg twice daily) with placebo in 28 patients with perennial nasal allergy who were allergic to house dust and mites in a double-blind randomized study. The number of inflammatory cells and decidual epithelial cells and concentrations of tryptase and eosinophil cationic protein in nasal lavages, and reactivity of the nasal mucosa to histamine and to antigen were investigated. The topical steroid, FP, significantly inhibited all of these assessments. The degree of improvement of nasal reactivity to histamine significantly correlated with the degree of decrease in eosinophil cationic protein levels.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 9/3/2009

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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