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Vol. 26, No. 2, 2009
Issue release date: October 2009
Section title: Original Paper
Fetal Diagn Ther 2009;26:75–80
(DOI:10.1159/000238113)

Prognostic Role of Tumor-Head Volume Ratio in Fetal Sacrococcygeal Teratoma

Sy E.D. · Filly R.A. · Cheong M.-L. · Clifton M.S. · Cortes R.A. · Ohashi S. · Takifuji K. · Ventura D.E. · Grethel E.J. · Wagner A.J. · Gress E.A. · Ball R.H. · Lee H. · Harrison M.R.
aDepartment of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan, ROC; bFetal Treatment Center, University of California, San Francisco, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/10/2008
Accepted: 12/9/2008
Published online: 9/11/2009

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

Objective: To evaluate the ability of a tumor-head volume ratio to predict outcome and incidence of hydrops in fetuses with sacrococcygeal teratoma. Methods: Seventy-one sonograms were reviewed retrospectively from 28 fetuses with sacrococcygeal teratoma managed in our institution. Head volume (HV) and total tumor volume were calculated from sonograms. Amount of cystic tumor was estimated to determine solid tumor volume (STV) for the STV/HV ratio. Results: Twenty percent of sonograms with STV/HV <1 and 97.3% with STV/HV >1 were associated with 1 or more abnormal sonographic signs (p = 0.000). Overall mortality was 11/27 (41%). There was no mortality in fetuses with a ratio of <1, while 11/18 (61%) of fetuses with ratio >1 died (p = 0.003). Conclusion: The STV/HV ratio may be used to identify fetuses with a high risk of a poor outcome due to high-output cardiac failure and hydrops, and may help guide management.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/10/2008
Accepted: 12/9/2008
Published online: 9/11/2009

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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