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Vol. 42, No. 6, 1996
Issue release date: 1996
Chemotherapy 1996;42:459–464

Immunomodulatory Action of Levofloxacin on Cytokine Production by Human Peripheral Blood Mononuclear Cells

Yoshimura T. · Kurita C. · Usami E. · Nakao T. · Watanabe S. · Kobayashi J. · Yamazaki F. · Nagai H.
aPharmaceutical Division, Ogaki Municipal Hospital, Ogaki, and bDepartment of Pharmacology, Gifu Pharmaceutical University, Gifu, Japan

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Levofloxacin (LVFX), the bacteriologically active isomer of ofloxacin, is a fluorinated quinolone. LVFX suppressed the proliferative activity of peripheral blood mononuclear cells (PBMC) stimulated with phytohemagglutinin (PHA). LVFX increased interleukin-2 (IL-2) production by PBMC stimulated with PHA in a dose-dependent manner, with more than 10 μg/ml of LVFX causing a significant increase. The granulocyte-macrophage colony-stimulating factor and soluble IL-2 receptor production by PHA-stimulated PBMC was suppressed at high concentrations of LVFX. Interleukin-1β production by lipopolysaccharide-stimulated PBMC was suppressed in a concentration-dependent manner by LVFX, and tumor necrosis factor-α production was suppressed at only the highest concentration. In contrast, interleukin-8 production was little affected by LVFX. These results show that LVFX has an immunomodulatory action on cytokines production by PBMC independent of its antimicrobial activity.

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