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Vol. 118, No. 2-4, 1999
Issue release date: February–April 1999
Int Arch Allergy Immunol 1999;118:268–270

Promoter Polymorphism in the Candidate Genes, IL–4, IL–9, TGF–β1, for Atopy and Asthma

Rosenwasser L.J.
Division of Allergy and Clinical Immunology, National Jewish Medical and Research Center, Denver, Colo., USA

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This paper will review genetic variations in the structure of three important candidate genes with varying effects in atopy and asthma that may have significant overall susceptibility associations in relation to the development of atopy and asthma. The three cytokine genes involved are interleukin (IL)–4, IL–9 and transforming growth factor β1, and the nature of the polymorphisms may be related to significantly higher outputs of these cytokines in atopy and asthma.

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    External Resources

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