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Table of Contents
Vol. 83, No. 3, 2009
Issue release date: October 2009
Urol Int 2009;83:300–305
(DOI:10.1159/000241672)

Micropapillary Pattern in Urothelial Carcinoma: A Clinicopathological Analysis

Alkibay T. · Sözen S. · Gürocak S. · Işik Gönül İ. · Poyraz A. · Üre İ.
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Abstract

Objectives: Our aim was to review our pathological archive to find out the actual incidence of micropapillary pattern (MPP) in our urothelial carcinoma patient population and determine its correlation with clinical outcome. Patients and Methods: 14 out of 170 cases with complete clinical follow-up were clinicopathologically analyzed. The extent of MPP was determined as tumor percentage. Results: 12 further cases with MPP were defined in the review. The percentage of patients with positive MPP increased in parallel to the tumor stage. There was no considerable difference between MPP-positive and MPP-negative groups according to the progression rates in non-muscle-invasive and muscle-invasive groups. Progression-free survival was much shorter in MPP cases, but again without statistical significance. Also, there was no significant relation between percentage of MPP and progression-free survival. Conclusions: Awareness of pathologists about MPP and its highly possible relation with aggressive behavior must be raised, as it may be more common than reported. A multicentric review of a large number of cases with MPP is needed for a better definition of its biological behavior. Focal MPP cases may have a better prognosis but this needs to be confirmed.



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References

  1. Amin MB, Ro JY, el-Sharkawy T, Lee KM, Troncoso P, Silva EG, Ordonez NG, Ayala AG: Micropapillary variant of transitional cell carcinoma of the urinary bladder. Histologic pattern resembling ovarian papillary serous carcinoma. Am J Surg Pathol 1994;18:1224–1232.
  2. Dhouib RS, Abbes I, Mrad K, Sassi S, Leila A, Driss M, Salah R, Romdhane KB: Micropapillary transitional cell carcinoma of the urinary bladder: report of two cases. Pathologica 2005;97:338–340.
  3. Kamat AM, Gee JR, Dinney CP, Grossman HB, Swanson DA, Millikan RE, Detry MA, Robinson TL, Pisters LL: The case for early cystectomy in the treatment of non-muscle-invasive micropapillary bladder carcinoma. J Urol 2006;175:881–885.
  4. Samaratunga H, Khoo K: Micropapillary variant of urothelial carcinoma of the urinary bladder; a clinicopathological and immunohistochemical study. Histopathology 2004;45:55–64.
  5. Maranchie JK, Bouyounes BT, Zhang PL, O’Donnell MA, Summerhayes IC, DeWolf WC: Clinical and pathological characteristics of micropapillary transitional cell carcinoma: a highly aggressive variant. J Urol 2000;163:748–751.
  6. Nassar H: Carcinomas with micropapillary morphology: clinical significance and current concepts. Adv Anat Pathol 2004;11:297–303.
  7. Oosterling W, Lobel B, Jakse G, Malmström PU, Stöckle M, Stenberg C: Guidelines on bladder cancer. Eur Urol 2002;41:105–112.
  8. Johansson SL, Borghede G, Holmang S: Micropapillary bladder carcinoma: a clinicopathologic study of 20 cases. J Urol 1999;161:1798–1802.
  9. Alvarado-Cabrero I, Sierra-Santiesteban FI, Mantilla-Morales A, Hernandez-Hernandez DM: Micropapillary carcinoma of the urothelial tract. A clinicopathologic study of 38 cases. Ann Diagn Pathol 2005;9:1–5.
  10. Fidaner C, Eser SY, Parkin DM: Incidence in Izmir in 1993–1994. First results from Izmir Cancer Registry. Eur J Cancer 2001;37:83–92.
  11. Kuroda N, Tamura M, Ohara M, Hirouchi T, Mizuno K, Miyazaki E: Invasive micropapillary carcinoma of the urinary bladder: an immunohistochemical study of neoplastic and stromal cells. Int J Urol 2006;13:1015–1018.
  12. Shueng-Wai Chan G, Wai-Kuen NG, Nicholls J, Kwok-Wah C: Acute renal failure secondary to an uncommon bladder tumor. Arch Pathol Lab Med 2005;129:53–54.
  13. Nishizawa K, Kobayashi T, Mitsumori K, Ide Y, Wtanebe J, Ogura K: Micropapillary bladder cancer. Int J Urol 2005;12:506–508.
  14. Maranchie JK, Bouyounes BT, Zhang OL, O’Donnell MA, Summerhayes IC, DeWolf WC: Clinical and pathological characteristics of micropapillary transitional cell carcinoma: a highly aggressive variant. J Urol 2000;163:748–751.
  15. Perez-Montial D, Wakely PE, Hes O, Michai M, Suster S: High-grade urothelial carcinoma of the renal pelvis: clinicopathologic study of 108 cases with emphasis on unusual morphologic variants. Mod Pathol 2006;19:494–503.
  16. Charfi S, Moussa A, Njim L, Toffahi M, Hadhri R, Mahmoudi H, Zakhama A: Micropapillary carcinoma. Prog Urol 2006;16:607–609.
  17. Kamat AM, Dinney CP, Gee JR, Grossman HB, Siefker-Radke AO, Tamboli P, Detry MA, Robinson TL, Pisters LL: Micropapillary bladder cancer: a review of the University of Texas M.D. Anderson Cancer Center experience with 100 consecutive patients. Cancer 2007;110:62–67.
  18. Vang R, Abrams J: A micropapillary variant of transitional cell carcinoma arising in the ureter. Arch Pathol Lab Med 2000;124:1347–1348.
  19. Gee JR, Kent DS, Millikan RE, Dinney CP, Grossman HB, Pisters LL: Micropapillary bladder carcinoma: preliminary results of BCG and neoadjuvant chemotherapy. J Urol 2002;167:262.

    External Resources

  20. Jozwicki W, Domaniewski J, Skok Z, Wolski Z, Domanowska E, Jozwicka G: Usefulness of histologic homogeneity estimation of muscle-invasive urinary bladder cancer in an individual prognosis: a mapping study. Urology 2005;66:1122–1126.


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