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Table of Contents
Vol. 55, No. 4, 2009
Issue release date: December 2009
Section title: Original Paper
Free Access
Ann Nutr Metab 2009;55:334–340

The Effect of Bifidobacterium lactis on the Growth of Infants: A Pooled Analysis of Randomized Controlled Studies

Steenhout P.G.a · Rochat F.b · Hager C.b
aNestlé Nutrition, Nestec Ltd., Vevey, and bNestlé Research Center, Lausanne, Switzerland
email Corresponding Author

Philippe G. Steenhout

Nestlé Nutrition

Av. Reller 22

CH–1800 Vevey (Switzerland)

Tel. +41 21 924 2974, Fax +41 21 924 4527, E-Mail philippe.steenhout@nestle.com


  1. WHO: Infant and young child nutrition resolution 54.2 of the World Health Assembly. Resolutions and Decisions of 54th World Health Assembly, 14–22 May 2001.
  2. WHO: Global strategy for infant and young child feeding. Resolutions and Decisions of 54th World Health Assembly, 14–22 May 2001.
  3. Kuan LW, Britto M, Decolongon J, Schoettker PJ, Atherton HD, Kotagal UR: Health system factors contributing to breastfeeding success. Pediatrics 1999;104:e28.
  4. Marchand L, Morrow MH: Infant feeding practices: understanding the decision-making process. Fam Med 1994;26:319–324.
  5. Simopoulos AP, Grave GD: Factors associated with the choice and duration of infant-feeding practice. Pediatrics 1984;74:603–614.
  6. Orne-Gliemann J, Mukotekwa T, Miller A, Perez F, Glenshaw M, Nesara P, Dabis F: Community-based assessment of infant feeding practices within a programme for prevention of mother-to-child HIV transmission in rural Zimbabwe. Public Health Nutr 2006;9:563–569.
  7. Riva E, Verduci E, Agostoni C, Giovannini M: Closer to the gold standard: an appraisal of formulae available in Italy for use in formula-fed infants. J Int Med Res 2005;33:595–611.
  8. Bongaerts G, Severijnen R, Timmerman H: Effect of antibiotics, prebiotics and probiotics in treatment for hepatic encephalopathy. Med Hypotheses 2005;64:64–68.
  9. Harmsen HJ, Wildeboer-Veloo AC, Raangs GC, Wagendorp AA, Klijn N, Bindels JG, Welling GW: Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr 2000;30:61–67.
  10. Wharton BA, Balmer SE, Scott PH: Sorrento studies of diet and fecal flora in the newborn. Acta Paediatr Jpn 1994;36:579–584.
  11. Balmer SE, Wharton BA: Diet and faecal flora in the newborn: breast milk and infant formula. Arch Dis Child 1989;64:1672–1677.
  12. Penders J, Vink C, Driessen C, London N, Thijs C, Stobberingh EE: Quantification of Bifidobacterium spp., Escherichia coli and Clostridium difficile in faecal samples of breast-fed and formula-fed infants by real-time PCR. FEMS Microbiol Lett 2005;243:141–147.
  13. Szajewska H, Mrukowicz JZ: Probiotics in the treatment and prevention of acute infectious diarrhea in infants and children: a systematic review of published randomized, double-blind, placebo-controlled trials. J Pediatr Gastroenterol Nutr 2001;33(suppl 2):S17–S25.
  14. Salminen S, Isolauri E: Intestinal colonization, microbiota, and probiotics. J Pediatr 2006;149:S115–S120.
  15. Vendt N, Grunberg H, Tuure T, Malminiemi O, Wuolijoki E, Tillmann V, Sepp E, Korpela R: Growth during the first 6 months of life in infants using formula enriched with Lactobacillus rhamnosus GG: double-blind, randomized trial. J Hum Nutr Diet 2006;19:51–58.
  16. Stratiki Z, Costalos C, Sevastiadou S, Kastanidou O, Skouroliakou M, Giakoumatou A, Petrohilou V: The effect of a bifidobacter supplemented bovine milk on intestinal permeability of preterm infants. Early Hum Dev 2007;83:575–579.
  17. Puccio G, Cajozzo C, Meli F, Rochat F, Grathwohl D, Steenhout P: Clinical evaluation of a new starter formula for infants containing live Bifidobacterium longum BL999 and prebiotics. Nutrition 2007;23:1–8.
  18. Weizman Z, Alsheikh A: Safety and tolerance of a probiotic formula in early infancy comparing two probiotic agents: a pilot study. J Am Coll Nutr 2006;25:415–419.
  19. Scientific Committee on Food: Report of the Scientific Committee on Food on the revision of essential requirements of infant formulae and follow-on formulae. Brussels, European Commission, 2003.
  20. Sombie I, Nacro B, Tiendrebeogo S, Dao B, Cartoux M, Meda N, Ky-Zerbo O, Dabis F, Mandelbrot L, Van de Perre P: Maternal HIV infection and the anthropometric characteristics of children at birth in Burkina Faso. DITRAME Study Group (in French). Santé 1999;9:173–177.
  21. Makasa M, Kasonka L, Chisenga M, Sinkala M, Chintu C, Filteau S: Early growth of infants of HIV-infected and uninfected Zambian women. Trop Med Intl Health 2007;12:594–602.
  22. Kuhn L, Kasonde P, Sinkala M, Kankasa C, Semrau K, Scott N, Tsai WY, Vermund SH, Aldrovandi GM, Thea DM: Does severity of HIV disease in HIV-infected mothers affect mortality and morbidity among their uninfected infants? Clin Infect Dis 2005;41:1654–1661.
  23. Urban MF, Bolton KD, Mokhachane M, Mphahlele RM, Bomela HN, Monaheng L, Beckh-Arnold E, Cooper PA: Growth of infants born to HIV-infected women when fed a biologically acidified starter formula with and without probiotics. S Afr J Clin Nutr 2008;21:28–32.
  24. Velaphi SC, Cooper PA, Bolton KD, Mokhachane M, Mphahlele RM, Beckh- Arnold E, Monaheng L, Haschke-Becher E: Growth and metabolism of infants born to women infected with human immunodeficiency virus and fed acidified whey-adapted starter formulas. Nutrition 2008;24:203–211.
  25. Gibson RA, Barclay D, Marshall H: Safety of supplementing infant formula with long-chain polyunsaturated fatty acids and Bifidobacterium lactis in term infants: a randomised controlled trial. Br J Nutr 2009;101:1706–1713.
  26. Rochat F, Brown C, Hager C, Puccio G, Fazzolari-Nesci A, Barclay D, Haschke F: Effect of a formula with adapted protein profile on intestinal microbiota and growth of infants. J Pediatr Gastroenterol Nutr 2005;41:508.
  27. Rochat F, Cherbut C, Barclay D: A whey-predominant formula induces fecal microbiota similar to that found in breast-fed infants. Nutr Res 2007;27:735–740.
  28. Zeigler EE, Jeter JM, Drulis JM, Nelson SE, Haschke F, Steenhout P, Brown C, Maire JC, Hager C: Formula with reduced content of improved, partially hydrolzed protein and probiotics: infant growth and health. Monatsschr Kinderheilkd 2003;151:S65–S71.
    External Resources
  29. WHO Anthro 2005 software. www.who.int/childgrowth/software/en (accessed September 8, 2009).