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Vol. 87, No. 6, 2009
Issue release date: November 2009
Section title: Clinical Study
Stereotact Funct Neurosurg 2009;87:379–384
(DOI:10.1159/000249819)

Chronic Deep Brain Stimulation for Segmental Dystonia

Woehrle J.C. · Blahak C. · Kekelia K. · Capelle H.-H. · Baezner H. · Grips E. · Weigel R. · Krauss J.K.
Departments of aNeurology and bNeurosurgery, Universitätsklinikum Mannheim, Mannheim, cDepartment of Neurosurgery, Medical School Hannover, MHH, Hannover, and dDepartment of Neurology, Katholisches Klinikum, Koblenz, Germany

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 4/23/2009
Accepted: 7/28/2009
Published online: 10/21/2009

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 1

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN

Abstract

Fourteen consecutive patients with segmental dystonia underwent chronic deep brain stimulation (DBS) surgery in the frame of a prospective study protocol. Twelve patients received chronic pallidal stimulation, while 2 patients with prominent dystonic tremor received chronic thalamic ventrointermediate nucleus stimulation. Twelve patients had primary dystonia, and 2 patients secondary dystonia. The Burke-Fahn-Marsden dystonia rating scale (BFM motor) showed a mean relative improvement of 57.3% at the first follow-up (FU1, mean 7 months) and 57.8% at the second follow-up (FU2, mean 16 months). The mean BFM scores were 34.9 ± 17.7 preoperatively, 14.9 ± 11.7 at FU1, and 14.8 ± 10.3 at FU2. Scores of the disability subscale improved by 43% at FU1 and 36% at FU2. Improvement was comparatively less in those patients with secondary dystonia. Dysarthria was a limitation of DBS in 4 patients when using high voltage. Overall, chronic DBS is a very effective treatment option for medically refractory segmental dystonia.


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 4/23/2009
Accepted: 7/28/2009
Published online: 10/21/2009

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 1

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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    External Resources

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