Intervirology 2010;53:76–81

Non-Invasive Evaluation of Hepatic Fibrosis for Type C Chronic Hepatitis

Tatsumi C.a · Kudo M.a · Ueshima K.a · Kitai S.a · Ishikawa E.a · Yada N.a · Hagiwara S.a · Inoue T.a · Minami Y.a · Chung H.a · Maekawa K.b · Fujimoto K.c · Kato M.c · Tonomura A.d · Mitake T.d · Shiina T.e
aDepartment of Gastroenterology and Hepatology, Kinki University School of Medicine, and bDivision of Abdominal Ultrasound, Department of Laboratory Medicine, Kinki University School of Medicine, Osaka-Sayama, cDepartment of Internal Medicine, National Hospital Organization Minami-Wakayama Medical Center, Tanabe, dHitachi Medical Corporation, Tokyo, and eHuman Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
email Corresponding Author

 goto top of outline Key Words

  • Biopsy, liver
  • FibroScan
  • Fibrosis, liver
  • Real-time tissue elastography

 goto top of outline Abstract

Objective: The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography® (RTE) and transient elastography (FibroScan®) methods. Methods: RTE, FibroScan and percutaneous liver biopsy were all performed on patients with chronic liver disease, particularly hepatitis C, to investigate liver fibrosis. Results: FibroScan and RTE were compared for fibrous liver staging (F stage), which was pathologically classified using liver biopsy. In FibroScan, significant differences were observed between F1/F3 and F2/F4, but no such differences were observed between F1/F2, F2/F3 and F3/F4. In RTE, significant differences were observed between F1/F2, F2/F3 and F2/F4. But for F3/F4, no significant differences were observed. Conclusion: FibroScan and RTE correlated well with F staging of the liver. In particular RTE was more successful than FibroScan in diagnosing the degree of liver fibrosis.

Copyright © 2010 S. Karger AG, Basel

 goto top of outline References
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 goto top of outline Author Contacts

Masatoshi Kudo, MD, PhD, Division of Gastroenterology and Hepatology
Department of Internal Medicine, Kinki University School of Medicine
377-2, Ohno-Higashi, Osaka-Sayama 589-8511 (Japan)
Tel. +81 72 366 0221, ext. 3149, Fax +81 72 367 2880

 goto top of outline Article Information

Published online: January 5, 2010
Number of Print Pages : 6
Number of Figures : 8, Number of Tables : 0, Number of References : 7

 goto top of outline Publication Details

Intervirology (International Journal of Basic and Medical Virology)

Vol. 53, No. 1, Year 2010 (Cover Date: January 2010)

Journal Editor: Liebert U.G. (Leipzig)
ISSN: 0300-5526 (Print), eISSN: 1423-0100 (Online)

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