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Vol. 53, No. 1, 2010
Issue release date: January 2010
Intervirology 2010;53:76–81
(DOI:10.1159/000252789)

Non-Invasive Evaluation of Hepatic Fibrosis for Type C Chronic Hepatitis

Tatsumi C.a · Kudo M.a · Ueshima K.a · Kitai S.a · Ishikawa E.a · Yada N.a · Hagiwara S.a · Inoue T.a · Minami Y.a · Chung H.a · Maekawa K.b · Fujimoto K.c · Kato M.c · Tonomura A.d · Mitake T.d · Shiina T.e
aDepartment of Gastroenterology and Hepatology, Kinki University School of Medicine, and bDivision of Abdominal Ultrasound, Department of Laboratory Medicine, Kinki University School of Medicine, Osaka-Sayama, cDepartment of Internal Medicine, National Hospital Organization Minami-Wakayama Medical Center, Tanabe, dHitachi Medical Corporation, Tokyo, and eHuman Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
email Corresponding Author

Abstract

Objective: The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography® (RTE) and transient elastography (FibroScan®) methods. Methods: RTE, FibroScan and percutaneous liver biopsy were all performed on patients with chronic liver disease, particularly hepatitis C, to investigate liver fibrosis. Results: FibroScan and RTE were compared for fibrous liver staging (F stage), which was pathologically classified using liver biopsy. In FibroScan, significant differences were observed between F1/F3 and F2/F4, but no such differences were observed between F1/F2, F2/F3 and F3/F4. In RTE, significant differences were observed between F1/F2, F2/F3 and F2/F4. But for F3/F4, no significant differences were observed. Conclusion: FibroScan and RTE correlated well with F staging of the liver. In particular RTE was more successful than FibroScan in diagnosing the degree of liver fibrosis.


 goto top of outline Key Words

  • Biopsy, liver
  • FibroScan
  • Fibrosis, liver
  • Real-time tissue elastography

 goto top of outline Abstract

Objective: The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography® (RTE) and transient elastography (FibroScan®) methods. Methods: RTE, FibroScan and percutaneous liver biopsy were all performed on patients with chronic liver disease, particularly hepatitis C, to investigate liver fibrosis. Results: FibroScan and RTE were compared for fibrous liver staging (F stage), which was pathologically classified using liver biopsy. In FibroScan, significant differences were observed between F1/F3 and F2/F4, but no such differences were observed between F1/F2, F2/F3 and F3/F4. In RTE, significant differences were observed between F1/F2, F2/F3 and F2/F4. But for F3/F4, no significant differences were observed. Conclusion: FibroScan and RTE correlated well with F staging of the liver. In particular RTE was more successful than FibroScan in diagnosing the degree of liver fibrosis.

Copyright © 2010 S. Karger AG, Basel


 goto top of outline References
  1. Sandrin L, Fourquet B, Hasquenoph JM, et al: Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 2003;29:1705–1713.
  2. Foucher J, Chanteloup E, Vergniol J, et al: Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut 2006;55:403–408.
  3. Fraquelli M, Rigamonti C, Casazza G, et al: Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease. Gut 2007;56:968–973.
  4. Fujimoto K, Wada S, Oshita M, et al: Non-invasive evaluation of hepatic fibrosis in patients with chronic hepatitis C using elastography. Medix Suppl 2007;24–27.
  5. Tatsumi C, Kudo M, Ueshima K, et al: Noninvasive evaluation of hepatic fibrosis using serum fibrotic markers, transient elastography (FibroScan) and real-time tissue elastography. Intervirology 2008;51(suppl 1):27–33.
  6. Itoh A, Ueno E, Tohno E, et al: Breast disease: clinical application of US elastography for diagnosis. Radiology 2006;239:341–350.
  7. Tsutsumi M, Miyagawa T, Matsumura T, et al: The impact of real-time tissue elasticity imaging (elastography) on the detection of prostate cancer: clinicopathological analysis. Int J Clin Oncol 2007;12:250–255.

 goto top of outline Author Contacts

Masatoshi Kudo, MD, PhD, Division of Gastroenterology and Hepatology
Department of Internal Medicine, Kinki University School of Medicine
377-2, Ohno-Higashi, Osaka-Sayama 589-8511 (Japan)
Tel. +81 72 366 0221, ext. 3149, Fax +81 72 367 2880
E-Mail m-kudo@med.kindai.ac.jp


 goto top of outline Article Information

Published online: January 5, 2010
Number of Print Pages : 6
Number of Figures : 8, Number of Tables : 0, Number of References : 7


 goto top of outline Publication Details

Intervirology (International Journal of Basic and Medical Virology)

Vol. 53, No. 1, Year 2010 (Cover Date: January 2010)

Journal Editor: Liebert U.G. (Leipzig)
ISSN: 0300-5526 (Print), eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Abstract

Objective: The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography® (RTE) and transient elastography (FibroScan®) methods. Methods: RTE, FibroScan and percutaneous liver biopsy were all performed on patients with chronic liver disease, particularly hepatitis C, to investigate liver fibrosis. Results: FibroScan and RTE were compared for fibrous liver staging (F stage), which was pathologically classified using liver biopsy. In FibroScan, significant differences were observed between F1/F3 and F2/F4, but no such differences were observed between F1/F2, F2/F3 and F3/F4. In RTE, significant differences were observed between F1/F2, F2/F3 and F2/F4. But for F3/F4, no significant differences were observed. Conclusion: FibroScan and RTE correlated well with F staging of the liver. In particular RTE was more successful than FibroScan in diagnosing the degree of liver fibrosis.



 goto top of outline Author Contacts

Masatoshi Kudo, MD, PhD, Division of Gastroenterology and Hepatology
Department of Internal Medicine, Kinki University School of Medicine
377-2, Ohno-Higashi, Osaka-Sayama 589-8511 (Japan)
Tel. +81 72 366 0221, ext. 3149, Fax +81 72 367 2880
E-Mail m-kudo@med.kindai.ac.jp


 goto top of outline Article Information

Published online: January 5, 2010
Number of Print Pages : 6
Number of Figures : 8, Number of Tables : 0, Number of References : 7


 goto top of outline Publication Details

Intervirology (International Journal of Basic and Medical Virology)

Vol. 53, No. 1, Year 2010 (Cover Date: January 2010)

Journal Editor: Liebert U.G. (Leipzig)
ISSN: 0300-5526 (Print), eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Sandrin L, Fourquet B, Hasquenoph JM, et al: Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 2003;29:1705–1713.
  2. Foucher J, Chanteloup E, Vergniol J, et al: Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut 2006;55:403–408.
  3. Fraquelli M, Rigamonti C, Casazza G, et al: Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease. Gut 2007;56:968–973.
  4. Fujimoto K, Wada S, Oshita M, et al: Non-invasive evaluation of hepatic fibrosis in patients with chronic hepatitis C using elastography. Medix Suppl 2007;24–27.
  5. Tatsumi C, Kudo M, Ueshima K, et al: Noninvasive evaluation of hepatic fibrosis using serum fibrotic markers, transient elastography (FibroScan) and real-time tissue elastography. Intervirology 2008;51(suppl 1):27–33.
  6. Itoh A, Ueno E, Tohno E, et al: Breast disease: clinical application of US elastography for diagnosis. Radiology 2006;239:341–350.
  7. Tsutsumi M, Miyagawa T, Matsumura T, et al: The impact of real-time tissue elasticity imaging (elastography) on the detection of prostate cancer: clinicopathological analysis. Int J Clin Oncol 2007;12:250–255.