Prostatic ductal adenocarcinomas may arise either in large primary periurethral prostatic ducts or in the peripheral prostatic ducts. Ductal adenocarcinomas are composed of tall columnar cells arranged in cribriform, papillary, solid, single glands, and PIN-like patterns. Other than the prostatic intraepithelial neoplasia (PIN)-like ductal pattern, which behaves like Gleason pattern 3, ductal adenocarcinoma is comparable to Gleason pattern 4 prostate cancer. Ductal adenocarcinoma can have a patchy basal cell layer and typically expresses prostate-specific antigen (PSA) immunohistochemically. Mimickers of ductal adenocarcinoma include prostatic urethral polyps, hyperplastic benign prostate glands, high-grade PIN, colorectal adenocarcinoma, and papillary urothelial carcinoma.
© 2009 S. Karger AG, Basel
- Prostate adenocarcinoma
- Ductal adenocarcinoma
- Gleason grade
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Prof. Jonathan I. Epstein
Departments of Pathology, Urology, and Oncology, The Johns Hopkins Hospital
600 N. Wolfe Street
Baltimore, MD 21287 (USA)
Tel. +1 410 955 5043, Fax +1 410 955 0115, E-Mail email@example.com
Received: May 17, 2009
Revised: May 21, 2009
Published online: December 09, 2009
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 0, Number of References : 19
Medical Principles and Practice (International Journal of the Kuwait University Health Sciences Centre)
Vol. 19, No. 1, Year 2010 (Cover Date: December 2009)
Journal Editor: Owunwanne A. (Kuwait)
ISSN: 1011-7571 (Print), eISSN: 1423-0151 (Online)
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