Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot Password? Reset your password

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login (Shibboleth)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Table of Contents
Vol. 28, No. 6, 2009
Issue release date: February 2010
Section title: Original Research Article
Free Access
Dement Geriatr Cogn Disord 2009;28:536–540

Vitamin E Use Is Associated with Improved Survival in an Alzheimer’s Disease Cohort

Pavlik V.N.a · Doody R.S.b · Rountree S.D.b · Darby E.J.b
Departments of aFamily and Community Medicine and bNeurology, Baylor College of Medicine, Houston, Tex., USA
email Corresponding Author

Valory N. Pavlik, PhD

Department of Family and Community Medicine

Baylor College of Medicine, 3701 Kirby Dr. Suite 600

Houston, TX 77098 (USA)

Tel. +1 713 798 3639, Fax +1 713 798 7940, E-Mail vpavlik@bcm.edu


  1. Engelhart MJ, Geerlings MI, Ruitenberg A, et al: Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 2002;287:3223–3229.
  2. Engelhart MJ, Ruitenberg A, Meijer J, et al: Plasma levels of antioxidants are not associated with Alzheimer’s disease or cognitive decline. Dement Geriatr Cogn Disord 2005;19:134–139.
  3. Zandi PP, Anthony JC, Khachaturian AS, et al: Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol 2004;61:82–88.
  4. Laurin D, Masaki KH, Foley DJ, White LR, Launer LJ: Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study. Am J Epidemiol 2004;159:959–967.
  5. Cherubini A, Martin A, Andres-Lacueva C, et al: Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study. Neurobiol Aging 2005;26:987–994.
  6. Sano M, Ernesto C, Thomas RG, et al: A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease: the Alzheimer’s Disease Cooperative Study. N Engl J Med 1997;336:1216–1222.
  7. Petersen RC, Thomas RG, Grundman M, et al: Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 2005;352:2379–2388.
  8. Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ: Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 2003;361:2017–2023.
  9. Miller ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E: Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:37–46.
  10. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C: Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 2007;297:842–857.
  11. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984;34:939–944.
  12. Doody R, Pavlik V, Massman P, et al: Changing patient characteristics and survival experience in an Alzheimer’s center patient cohort. Dement Geriatr Cogn Disord 2005;20:198–208.
  13. Doody RS, Dunn JK, Huang E, Azher S, Kataki M: A method for estimating duration of illness in Alzheimer’s disease. Dement Geriatr Cogn Disord 2004;17:1–4.
  14. Folstein M, Folstein S, McHugh P: ‘Mini-Mental State’: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198.
  15. Klein EA, Thompson IM, Lippman SM, et al: SELECT: the Selenium and Vitamin E Cancer Prevention Trial. Urol Oncol 2003;21:59–65.
  16. Roberts L, Oates J, Linton M, et al: The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic Biol Med 2007;43:1388–1393.