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Neuroepidemiology 2010;34:34–42

Validation of the Telephone Interview for Cognitive Status-modified in Subjects with Normal Cognition, Mild Cognitive Impairment, or Dementia

Knopman D.S.a, b · Roberts R.O.b, c · Geda Y.E.b–d · Pankratz V.S.b, e · Christianson T.J.H.b, e · Petersen R.C.a, b · Rocca W.A.a, c
aDepartment of Neurology, bMayo Clinic Alzheimer’s Disease Research Center, cDivision of Epidemiology, Department of Health Sciences Research, dDepartment of Psychiatry and Psychology, eDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minn., USA
email Corresponding Author

 goto top of outline Key Words

  • Dementia
  • Mild cognitive impairment
  • Telephone Interview for Cognitive Status-modified

 goto top of outline Abstract

Background: The telephone assessment of cognitive functions may reduce the cost and burden of epidemiological studies. Methods: We validated the Telephone Interview for Cognitive Status-modified (TICS-m) using an extensive in-person assessment as the standard for comparison. Clinical diagnoses of normal cognition, mild cognitive impairment (MCI), or dementia were established by consensus of physician, nurse, and neuropsychological assessments. Results: The extensive in-person assessment classified 83 persons with normal cognition, 42 persons with MCI, and 42 persons with dementia. There was considerable overlap in TICS-m scores among the three groups. Receiver operating characteristic curves identified ≤31 as the optimal cutoff score to separate subjects with MCI from subjects with normal cognition (sensitivity = 71.4%; subjects with dementia excluded), and ≤27 to separate subjects with dementia from subjects with MCI (sensitivity = 69.0%; subjects with normal cognition excluded). The TICS-m performed well when subjects with MCI were pooled either with subjects with dementia (sensitivity = 83.3%) or with subjects with normal cognition (sensitivity = 83.3%). Conclusions: Although the TICS-m performed well when using a dichotomous classification of cognitive status, it performed only fairly in separating MCI from either normal cognition or dementia. The TICS-m should not be used as a free-standing tool to identify subjects with MCI, and it should be used with caution as a tool to detect dementia.

Copyright © 2009 S. Karger AG, Basel

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 goto top of outline Author Contacts

Dr. David S. Knopman
Department of Neurology, College of Medicine
Mayo Clinic, 200 First Street SW
Rochester, MN 55905 (USA)
Tel. +1 507 538 1038, Fax +1 507 538 6012, E Mail

 goto top of outline Article Information

Conflict of Interest: Dr. Knopman has served on a Data Safety Monitoring Board for Sanofi-Aventis and serves on a Data Safety Monitoring Board for Lilly. He served as a consultant to GlaxoSmithKline. He is also an investigator in a clinical trial sponsored by Elan Pharmaceuticals. Dr. Petersen has been a consultant to GE HealthCare, Servier, and Elan Pharmaceuticals.

Received: June 17, 2009
Accepted: September 7, 2009
Published online: November 5, 2009
Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 5, Number of References : 28

 goto top of outline Publication Details


Vol. 34, No. 1, Year 2010 (Cover Date: January 2010)

Journal Editor: Feigin V.L. (Auckland)
ISSN: 0251-5350 (Print), eISSN: 1423-0208 (Online)

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