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Vol. 21, No. 2-4, 1998
Issue release date: 1998

Cloning of a Human Renal p–Aminohippurate Transporter, hROAT1

Reid G. · Wolff N.A. · Dautzenberg F.M. · Burckhardt G.
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  1. Pritchard JB, Miller DS: Mechanisms mediating renal secretion of organic anions and cations. Physiol Rev 1993;73:765–796.
  2. Pritchard JB: Coupled transport of p–aminohippurate by rat kidney basolateral membrane vesicles. Am J Physiol 1988;255:F597–F604.

    External Resources

  3. Shimada H, Moewes B, Burckhardt G: Indirect coupling to Na+ of p–aminohippuric acid uptake into rat renal basolateral membrane vesicles. Am J Physiol 1987;253:F795–F801.

    External Resources

  4. Ullrich KJ: Renal transporters for organic anions and organic cations. Structural requirements for substrates. J Membr Biol 1997;158: 95–107.
  5. Sekine T, Watanabe N, Hosoyamada M, Kanai N, Endou H: Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 1997;272:18526– 18529.
  6. Sweet DH, Wolff NA, Pritchard JB: Expression cloning and characterization of ROAT1. J Biol Chem 1997;272:30088–30095.
  7. Wolff NA, Werner A, Burkhardt S, Burckhardt G: Expression cloning and characterization of a renal organic anion transporter from winter flounder. FEBS Lett 1997;417:287–291.
  8. Koepsell H: Organic cation transporters in intestine, kidney, liver, and brain. Annu Rev Physiol 1998;60:243–266.
  9. Frohman MA, Dush MK, Martin GR: Rapid production of full–length cDNAs from rare transcripts. Amplification using a single gene–specific oligonucleotide primer. Proc Natl Acad Sci USA 1988;85:8998–9002.
  10. Harvey RJ, Vreudgenhill E, Zaman SH, Bhandal NS, Usherwood PNR, Barnard EA, Darlison MG: Sequence of a functional invertebrate GABAA receptor subunit which can form a chimeric receptor with a vertebrate a subunit. EMBO J 1991;10:3239–3245.

    External Resources

  11. Dautzenberg FM, Dietrich K, Palchaudhuri MR, Spiess J: Identification of two corticotropin–releasing factor receptors from Xenopus laevis with high ligand selectivity: Unusual pharmacology of the type 1 receptor. J Neurochem 1997;69:1640–1649.

    External Resources

  12. von Heijne G: Membrane protein structure prediction, hydrophobicity analysis and the positive–inside rule. J Mol Biol 1992;225:487– 494.

    External Resources

  13. Lopez–Nieto CE, You GF, Bush KT, Barros EJG, Beier DR, Nigam SK: Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem 1997;272:6471–6478.
  14. Roch–Ramel F, Guisan B, Schild L: Indirect coupling of urate and p–aminohippurate transport to sodium in human brush–border membrane vesicles. Am J Physiol 1996;270:F61– F68.

    External Resources

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