Construction of Relational Topographies from the Quantitative Measurements of Functional Deep Brain Stimulation Using a ‘Roving Window’ Interpolation AlgorithmShenai M.B. · Walker H. · Guthrie S. · Watts R. · Guthrie B.L.
The delivery of stimulus by a deep brain stimulation (DBS) contact electrode at a particular location may lead to a quantifiable physiologic effect, both intraoperatively and postoperatively. Consequently, measured data values can be attributed to discrete scattered points in neuroanatomic space, allowing for interpolative techniques to generate a topographic map of spatial patterns. Ultimately, by relating the topographies of various intraoperative measurements to the postoperative counterparts and neuroanatomic atlases, outcome-guided adjustments to electrode position can be pursued intraoperatively. In this study, 52 Parkinson’s disease patients were tested with a postoperative trial of stimulation and thresholds were recorded for motor adverse effects. A ‘roving window’ interpolation algorithm was adapted to generate a topographic map of voltage threshold along selected axial, coronal and sagittal planes. By developing these relational topographies for a variety of intraoperative and postoperative effects, a multivariable approach towards DBS optimization emerges.
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