Cover

Frontiers in Eating and Weight Regulation

Editor(s): Langhans W. (Schwerzenbach) 
Geary N. (Schwerzenbach) 
Table of Contents
Vol. 63, No. , 2010
Section title: Paper

Hypothalamic Nutrient Sensing and Energy Balance

Moran T.H.
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Abstract

Hypothalamic neurons have the capacity to sense and alter their activity in response to fluctuations in local nutrient concentrations. Alterations in glucose, fatty acid and amino acid concentrations have all been demonstrated to affect neuronal excitability and/or intracellular signaling pathways. The degree to which such changes in nutrient availability have the capacity to modify energy balance varies across nutrient type. The underlying mechanisms through which various nutrients affect food intake and overall energy balance involve both specific and shared neuronal substrates.



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References

  1. Mayer J: Glucostatic mechanism of regulation of food intake. N Engl J Med 1953;249:13-16
  2. Oomura Y, Kimura K, Ooyama H, Maeo T, Iki M, Kuniyoshi N: Recipricol activites of the ventrome-dial and lateral hypothalamic areas in cats. Science 1964;143:484-485
  3. Fioramonti X, et al: Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio-melanocortin networks?. Diabetes 2007;56:1219-1227
  4. Levin BE, Dunn-Meynell AA, Routh VH: Brain glucosensing and the K(ATP) channel. Nat Neurosci 2001;4:459-460
  5. Levin B: Neuronal glucose sensing: still a physiological orphan. Cell Metab 2007;6:252-254
  6. Wang R, et al: The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes 2004;53:1959-1965
  7. Spanswick D, et al: Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 1997;390:521-525
  8. Spanswick D, et al: Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 2000;3:757-758
  9. Stunkard AJ, Wolff HG: Studies on the physiology of hunger. I. The effect of intravenous glucose administration on gastric hunger contractions in man. J Clin Invest 1956;35:954-963
  10. Smith GP, Epstein AN: Increased feeding in response to decreased glucose utilization in the rat and monkey. Am J Physiol 1969;217:1083-1087
  11. Miselis RR, Epstein AN: Feeding induced by intracerebroventricular 2-deoxy-D-glucose in the rat. Am J Physiol 1975;229:1438-1447
  12. Smith G, Gibbs J, Stromayer AJ, Stokes PR: Threshold doses of 2-deoxy-D-glucose for hyperglycemia and feeding in rats and monkeys. American Journal of Physiology 1972;222:77-81
  13. Ritter S, Dinh TT, Li AJ: Hindbrain catecholamine neurons control multiple glucoregulatory responses. Physiol Behav 2006;89:490-500
  14. Campfield LA, Brandon P, Smith FJ: On-line continuous measurement of blood glucose and meal pattern in free-feeding rats: the role of glucose in meal initiation. Brain Res Bull 1985;14:605-616
  15. Campfield LA, Smith FJ: Transient declines in blood glucose signal meal initiation. Int J Obes 1990;14:(suppl 3)15-31discussion31-34
  16. Melanson KJ, et al: Blood glucose patterns and appetite in time-blinded humans: carbohydrate versus fat. Am J Physiol 1999;277:R337-R345
  17. Smith FJ, Campfield LA: Meal initiation occurs after experimental induction of transient declines in blood glucose. Am J Physiol 1993;265:R1423-R1429
  18. Dunn-Meynell AA, et al: Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding. J Neurosci 2009;29:7015-7022
  19. Parton LE, et al: Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 2007;449:228-232
  20. Oomura Y, et al: Effect of free fatty acid on the rat lateral hypothalamic neurons. Physiol Behav 1975;14:483-486
  21. Wang R, et al: Effects of oleic acid on distinct populations of neurons in the hypothalamic arcuate nucleus are dependent on extracellular glucose levels. J Neurophysiol 2006;95:1491-1498
  22. Le Foll C, Irani BG, Magnan C, Dunn-Meynell AA, Levin BE: Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing. Am J Physiol Regul Integr Comp Physiol 2009;297:R655-R664
  23. Loftus TM, et al: Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 2000;288:2379-2381
  24. Miller I, et al: Anorexigenic C75 alters c-Fos in mouse hypothalamic and hindbrain subnuclei. Neuroreport 2004;15:925-929
  25. Kim EK, et al: Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment. Am J Physiol Endocrinol Metab 2002;283:E867-E879
  26. Aja S, et al: Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight. Am J Physiol Regul Integr Comp Physiol 2008;294:R352-R361
  27. Yang N, et al: C75 [4-methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid] activates carnitine palmitoyltransferase-1 in isolated mitochondria and intact cells without displacement of bound malonyl CoA. J Pharmacol Exp Ther 2005;312:127-133
  28. Thupari JN, et al: C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci USA 2002;99:9498-9502
  29. Mera P, et al: C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyl-transferase 1 and decreases food intake and body weight. Biochem Pharmacol 2009;77:1084-1095
  30. Kim EK, et al: C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. J Biol Chem 2004;279:19970-19976
  31. Obici S, et al: Central administration of oleic acid inhibits glucose production and food intake. Diabetes 2002;51:271-275
  32. Morgan K, Obici S, Rossetti L: Hypothalamic responses to long-chain fatty acids are nutritionally regulated. J Biol Chem 2004;279:31139-31148
  33. Gao S, et al: Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci USA 2007;104:17358-17363
  34. Minokoshi Y, et al: AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004;428:569-574
  35. Lam TK, et al: Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 2005;11:320-327
  36. Obici S, et al: Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med 2003;9:756-761
  37. He W, et al: Molecular disruption of hypothalamic nutrient sensing induces obesity. Nat Neurosci 2006;9:227-233
  38. Dai Y, et al: Localization and effect of ectopic expression of CPT1c in CNS feeding centers. Biochem Biophys Res Commun 2007;359:469-474
  39. Hu Z, et al: A role for hypothalamic malonyl-CoA in the control of food intake. J Biol Chem 2005;280:39681-39683
  40. Wolfgang MJ, Lane MD: Hypothalamic malonylcoenzyme A and the control of energy balance. Mol Endocrinol 2008;22:2012-2020
  41. Lane MD, Cha SH: Effect of glucose and fructose on food intake via malonyl-CoA signaling in the brain. Biochem Biophys Res Commun 2009;382:1-5
  42. Wolfgang MJ, et al: Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. J Neurochem 2008;105:1550-1559
  43. Wolfgang MJ, et al: The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc Natl Acad Sci USA 2006;103:7282-7287
  44. Cota D, et al: Hypothalamic mTOR signaling regulates food intake. Science 2006;312:927-930
  45. Wullschleger S, Loewith R, Hall MN: TOR signaling in growth and metabolism. Cell 2006;124:471-484
  46. Cota D, et al: The role of hypothalamic mammalian target of rapamycin complex 1 signaling in dietinduced obesity. J Neurosci 2008;28:7202-7208
  47. Kimball SR, Jefferson LS: Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr 2006;136:(1 suppl)227S-231S
  48. Potier M, Darcel N, Tome D: Protein, amino acids and the control of food intake. Curr Opin Clin Nutr Metab Care 2009;12:54-58
  49. Ropelle ER, et al: A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Diabetes 2008;57:594-605
  50. Morrison CD, et al: Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism. Am J Physiol Endocrinol Metab 2007;293:E165-E171


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