Cover

Frontiers in Eating and Weight Regulation

Editor(s): Langhans W. (Schwerzenbach) 
Geary N. (Schwerzenbach) 
Table of Contents
Vol. 63, No. , 2010
Section title: Paper
Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 186–194
(DOI:10.1159/000264406)

Metabolic Imprinting in Obesity

Sullivan E.L. · Grove K.L.
Division of Neuroscience, Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oreg., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/27/2009
Cover Date: 2010

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9300-7 (Print)
eISBN: 978-3-8055-9301-4 (Online)

Abstract

Increasing evidence indicates that early metabolic programming contributes to escalating obesity rates in children and adults. Metabolic imprinting is involved in the establishment of set points for physiologic and metabolic responses in adulthood. Evidence from epidemiological studies and animal models indicates that maternal health and nutritional status during gestation and lactation have long-term effects on central and peripheral systems that regulate energy balance in the developing offspring. Perinatal nutrition also impacts susceptibility to developing metabolic disorders and plays a role in programming body weight set points. The states of maternal energy status and health that are implicated in predisposing offspring to increased risk of developing obesity include maternal overnutrition, diabetes, and undernutrition. This chapter discusses the evidence from epidemiologic studies and animal models that each of these states of maternal energy status results in metabolic imprinting of obesity in offspring. Also, the potential molecular mediators of metabolic imprinting of obesity by maternal energy status including glucose, insulin, leptin, inflammatory cytokines and epigenetic mechanisms are considered.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/27/2009
Cover Date: 2010

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9300-7 (Print)
eISBN: 978-3-8055-9301-4 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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