Frontiers in Eating and Weight Regulation

Editor(s): Langhans W. (Schwerzenbach) 
Geary N. (Schwerzenbach) 
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Metabolic Imprinting in Obesity

Sullivan E.L. · Grove K.L.
Division of Neuroscience, Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oreg., USA Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 186–194 (DOI:10.1159/000264406)


Increasing evidence indicates that early metabolic programming contributes to escalating obesity rates in children and adults. Metabolic imprinting is involved in the establishment of set points for physiologic and metabolic responses in adulthood. Evidence from epidemiological studies and animal models indicates that maternal health and nutritional status during gestation and lactation have long-term effects on central and peripheral systems that regulate energy balance in the developing offspring. Perinatal nutrition also impacts susceptibility to developing metabolic disorders and plays a role in programming body weight set points. The states of maternal energy status and health that are implicated in predisposing offspring to increased risk of developing obesity include maternal overnutrition, diabetes, and undernutrition. This chapter discusses the evidence from epidemiologic studies and animal models that each of these states of maternal energy status results in metabolic imprinting of obesity in offspring. Also, the potential molecular mediators of metabolic imprinting of obesity by maternal energy status including glucose, insulin, leptin, inflammatory cytokines and epigenetic mechanisms are considered.


Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

Pay-per-View Options
Direct payment This item at the regular price: USD 33.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 23.00