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Studying Regression of Seborrheic Keratosis in Lichenoid Keratosis with Sequential Dermoscopy Imaging

Zaballos P.a · Salsench E.a · Serrano P.a · Cuellar F.b · Puig S.b · Malvehy J.b
aDepartment of Dermatology, Hospital de Sant Pau i Santa Tecla, Tarragona, and bDepartment of Dermatology, Melanoma Unit, Hospital Clinic, IDIBAPS, Barcelona, Spain Dermatology 2010;220:103–109 (DOI:10.1159/000265556)


Background: Lichenoid keratosis (LK) is a well-described entity that has been proposed to represent a regressive response to a pre-existent epidermal lesion. Aims: To evaluate the natural evolution of a series of cases showing the intermediate stage of the regression of seborrheic keratosis in LK using sequential dermoscopy imaging over time. Material and Methods: A series of lesions with dermoscopic areas of seborrheic keratosis and LK in the same tumor were consecutively collected for over 3 years at the Dermatology Department of the Hospital de Sant Pau i Santa Tecla, Tarragona, Spain. Sequential dermoscopic images of each case were collected quarterly for 1 year. At the end of the follow-up, all the lesions were biopsied. Results: A total of 22 cases were collected. At the end of the follow-up, the LK part increased in all the lesions. In 11 cases (50%), the seborrheic keratosis part disappeared completely, and in another 5 cases (22.7%), seborrheic keratosis comprised only 10% of the remaining area. Conclusions: These dermoscopic study findings support the proposal that LK represents a regressive response to a pre-existent epidermal lesion, in this case seborrheic keratosis.


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