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Vol. 39, No. 3, 1999
Issue release date: April 1999
Neuropsychobiology 1999;39:141–143

Apolipoprotein E Genotype and Schizophrenia

Chen J.-Y. · Hong C.-J. · Chiu H.-J. · Lin C.-Y. · Bai Y.-M. · Song H.-L. · Lai H.-C. · Tsai S.-J.
aSection of Psychiatry, Yu-Li Veterans Hospital, bDivision of Psychiatry, School of Medicine, National Yang-Ming University, and cDepartment of Psychiatry, Veterans General Hospital, Taipei, Taiwan, ROC

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Schizophrenic disorders are complex genetic disorders and may involve multiple genes of small effect. The presence of apolipoprotein E (apoE) is associated with several neuropsychiatric disorders. Previous studies on apoE genotype distribution in schizophrenia have reported conflicting findings. We studied the genotype frequencies in a large group of schizophrenic patients. The genotype distribution was significantly different between the schizophrenic patients and the control subjects. Persons who were σ3 carriers have an increased risk of schizophrenia. This result suggests that apoE isoforms may play a functional role in the pathogenesis of schizophrenic disorders. Some possible mechanisms regarding the effect of apoE on the development of schizophrenia are discussed.

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