Journal Mobile Options
Table of Contents
Vol. 40, No. 4, 1999
Issue release date: November 1999

Mild Cognitive Impairment in Old-Age Depression Is Associated with Increased EEG Slow-Wave Power

Adler G. · Bramesfeld A. · Jajcevic A.
To view the fulltext, log in and/or choose pay-per-view option

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Abstract

Reversible dementia in geriatric depression is known to be a risk factor for irreversible dementia. Whether just mild cognitive deficits in elderly depressed patients hold a similar risk is not known yet. It may be suggested that elderly depressed patients with mild cognitive deficits, who are prone to develop dementia, show EEG alterations similar to those observed in demented patients. We studied the relationships between cognitive performance, severity of depressive symptoms and quantitative EEG parameters in 31 unmedicated, nondemented, depressed patients aged 60 years or more. Twenty-one of the patients showed a cognitive performance characteristic of mild cognitive impairment. In these patients, the mean delta and theta power was significantly higher than in the patients without cognitive impairment. Total delta power was negatively correlated with cognitive performance. There was no relationship between cognitive performance or EEG parameters and the severity of depression.

Copyrightz1999S.KargerAG,Basel



Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Jorm AF, van Duijn CM, Chandra V, Fratiglioni L, Graves AB, Heyman A, Kokmen E, Kondo K, Mortimer JA, Rocca WA: Psychiatric history and related exposures as risk factors for Alzheimer’s disease: A colloborative re-analysis of case control studies. EURODERM Risk Factors Research Group, Int J Epidemiol 1991;20(suppl 2):43–47.
  2. Alexopoulos GS, Meyers BM, Young RC, Mattis S, Kakuma T: The course of geriatric depression with ‘reversible dementia’: A controlled study. Am J Psychiatry 1993;150:1693–1699.
  3. Abas MA, Sahakian BJ, Levy R: Neuropsychological deficits and CT scan changes in elderly depressives. Psychol Med 1990;20:507–520.
  4. Tarbuck AF, Paykel ES: Effects of major depression on the cognitive function of younger and older subjects. Psychol Med 1995;25:285–296.
  5. Flicker C, Ferries SH, Reisberg B: Mild cognitive impairment in the elderly. Neurology 1991;41:1006–1009.
  6. Morris JC, Storandt M, McKeel DW, Rubin EH, Price JL, Grant EA, Berg L: Cerebral amyloid deposition and diffuse plaques in ‘normal’ aging: Evidence for presymptomatic and very mild Alzheimer’s disease. Neurology 1996;46:707–719.
  7. Schofield PW, Marder K, Dooneief G, Jacobs DM, Sano M, Stern Y: Association of subjective memory complaints with subsequent cognitive decline in community dwelling elderly individuals with baseline cognitive impairment. Am J Psychiatry 1997;154:609–615.
  8. Sloan EP, Fenton GW, Kennedy NS, MacLennan JM: Electro-encephalography and single photon emission computed tomography in dementia: A comparative study. Psychol Med 1995;25:631–638.
  9. Müller HF, Engelsmann F, Vasavan Nair NP, Robitaille Y: Psychogeriatric clinical, electroencephalographic and autopsy findings. Neuropsychobiology 1997;35:95–101.
  10. O’Connor KP, Shaw JC, Ongley CO: The EEG and differential diagnosis in psychogeriatrics. Br J Psychiatry 1979;135:156–162.
  11. Brenner RP, Ulrich RF, Spiker DG, Sclabassi RJ, Reynolds CF, Marin RS, Boller F: Computerized EEG spectral analysis in elderly normal, demented and depressed subjects. Electroencephalogr Clin Neurophysiol 1986;64:483–492.
  12. Coben LA, Chi D, Snyder AZ, Storandt M: Replication of a study of frequency analysis of the resting awake EEG in mild probable Alzheimer’s disease. Electroencephalogr Clin Neurophysiol 1990;75:148–145.
  13. Ihl R, Dierks T, Martin EM, Frölich L, Maurer K: Topography of the maximum of EEG frequency bands in dementia of the Alzheimer’s type. Biol Psychiatry 1996;39:319–325.
  14. Müller TJ, Thome J, Chiarmonti R, Dierks T, Maurer K, Fallgatter AJ, Fröhlich L, Scheubeck M, Strik WK: A comparison of qEEG and HAMPAO-SPECT in relation to the clinical severity of Alzheimer’s disease. Eur Arch Psychiatry Clin Neurosci 1997;247:259–263.
  15. Förstl H, Besthorn C, Sattel H, Zerfaß R, Geiger-Kabisch C, Schreiber-Gasser U, Hentschel F: Volumetrische Hirnveränderungen und quantitatives EEG bei normalem Altern und Alzheimer-Demenz. Nervenarzt 1996;67:53–61.
  16. Dierks T, Frölich L, Ihl R, Maurer K: Correlation between cognitive brain function and electrical brain activity in dementia of the Alzheimer type. J Neural Transm 1995;99:55–62.

    External Resources

  17. Williamson PC, Merskey H, Morrison S, Rabheru K, Fox H, Wands K, Wong C, Hachinski V: Quantitative electro-encephalographic correlates of cognitive decline in normal elderly subjects. Arch Neurol 1990;47:1185–1188.
  18. Folstein MF, Folstein SE, McHugh PR: ‘Mini mental state’: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198.
  19. Hamilton M: Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967;6:278–296.
  20. Zaudig M, Hiller W: Strukturiertes Interview für die Diagnose einer Demenz vom Alzheimer Typ, der Multiinfarkt- (oder vaskulären) Demenz und Demenzen anderer Ätiologie nach DSM-III-R, DSM-IV und ICD-10: SIDAM. Bern, Huber, 1996.
  21. Zaudig M, Mittelhammer J, Hiller W, Pauls A, Thora C, Morinigo A, Mombour W : SIDAM – A structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia and dementias of other aetiology according to ICD-10 and DSM-III-R. Psychol Med 1991;21:225–236.
  22. Katznelson RD: EEG recording, electrode placement, and aspects of generator localization; in Nuñez PL (ed): Electrical Fields of the Brain. New York, Oxford University Press, 1981.
  23. Semlitsch HV, Anderer P, Saletu B, Schuster P, Presslich O: A solution for reliable and valid reduction of ocular artifacts to the P300 ERP. Psychophysiology 1986;23:695–703.
  24. Versavel M, Leonard P, Herrman WM: Standard operating procedure for the registration and computer-supported evaluation of pharmaco-EEG data. Neuropsychobiology 1995;32:166–170.
  25. Kuskowski MA, Mortimer JA, Morley GK, Malone SM, Okaya AJ: Rate of cognitive decline in Alzheimer’s disease is associated with EEG alpha power. Biol Psychiatry 1993;33:659–662.
  26. Soininen H, Partanen J, Pääkkönen A, Koivisto E, Riekkinen PJ: Changes in absolute power values of EEG spectra in the follow-up of Alzheimer’s disease. Acta Neurol Scand 1991;83:133–136.
  27. Soininen H, Partanen J, Laulumaa V, Paakkonen A, Helkala EL, Riekkinen PJ: Serial EEG in Alzheimer’s disease: 3-year follow-up and clinical outcome. Electroencephalogr Clin Neurophysiol 1991;79:342–348.
  28. Cavanaugh SVA, Wettstein RM: The relationship between severity of depression, cognitive dysfunction and age in medical inpatients. Am J Psychiatry 1983;140:495–496.

    External Resources

  29. O’Carroll R, Whittick J, Baikie E: Parietal signs and sinister prognosis in dementia, a four-year follow-up study. Br J Psychiatry 1991;158:358–361.
  30. Boller F, Becker JT, Holland AL, Forbes MM, Hood PC, McGonigle-Gibson KL: Predictors of decline in Alzheimer’s disease. Cortex 1991;27:9–17.
  31. Helkala EL, Laulumaa V, Soininen H: Different patterns of cognitive decline related to normal or deteriorating EEG in a 3-year follow-up study of patients with Alzheimer’s disease. Neurology 1991;41:528–532.
  32. Tröster AI, Stalp LD, Paolo AM, Fields JA, Koller WC: Neuro-psychological impairment in Parkinson’s disease with and without depression. Arch Neurol 1995;52:1164–1169.
  33. Alexopoulos GS, Meyers BM, Young RC, Campbell S, Silbersweig D, Charlson M: ‘Vascular depression’ hypothesis. Arch Gen Psychiatry 1997;54:915–922.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50