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Vol. 42, No. 2, 2000
Issue release date: July 2000
Section title: Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper
Neuropsychobiology 2000;42:58–61
(DOI:10.1159/000026673)

Aggressive Behavioral Characteristics and Endogenous Hormones in Women with Bulimia nervosa

Cotrufo P. · Monteleone P. · d’Istria M. · Fuschino A. · Serino I. · Maj M.
aInstitute of Psychiatry and bDepartment of Fisiologia Umana and Funzioni Biologiche Integrate ‘F. Bottazzi’, University of Naples SUN, Naples, Italy

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 7/28/2000

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Increased aggressiveness frequently occurs in patients with bulimia nervosa (BN), but its neurobiological correlates have been poorly investigated. In this study, we investigated possible relationships between such clinical measure and blood levels of endogenous hormones in patients with BN. Morning plasma levels of testosterone, 17β-estradiol, prolactin (PRL) and cortisol were measured in 33 bulimic women and 22 healthy female controls. The eating-related psychopathology, depression and aggressiveness were rated by specific psychometric scales. Bulimic patients showed decreased plasma levels of PRL and 17β-estradiol, and increased concentrations of cortisol and testosterone. Moreover, patients scored higher than healthy controls on rating scales assessing eating-related psychopathology, depressive symptoms and aggressiveness. A significant positive correlation was found between testosterone plasma levels and aggressiveness in patients but not in controls. These findings suggest that in BN, increased plasma levels of testosterone may play a role in the modulation of aggressiveness.


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 7/28/2000

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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    External Resources

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